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A Short-Term Long-Chain Triglycerides Infusion Has No Influence on Immune Function of Adult Patients Undergoing Gastrointestinal Surgery

Xiaogang Li, MD^*, Jiaoqian Ying, MD^*, Shan Zeng, MD, Liangfang Shen, PhD, Xiaoping Wan, PhD^*, Xiaorong Li, PhD, Hui Tan, MD^*, Haiping Pei, MD^*, Jun Zhou, MD^* and Hong Shen, MD

From the ^* Department of General Surgery, Medical Research Center, Department of Tumor, Xiangya Hospital, Central South University, Changsha, Hunan, China; and the Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, China

Correspondence: Hong Shen, Medical Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008. Electronic mail may be sent to hongshen2000{at}yahoo.com.

Background: Parenteral nutrition (PN) support containing long-chain triglycerides (LCT) plays a critical supportive role in surgical patients' management. This study aims to investigate the effects of intravenous (IV) LCT emulsion on human immune function in adult patients receiving a gastrointestinal surgical procedure. Methods: Sixty adult patients were randomly assigned either to the LCT treatment group (n = 32) or to the control group (n = 28). After an abdominal operation, the subjects received PN treatment with or without LCT for 5 days. Neutrophil, peripheral blood mononuclear cell (PBMC), lymphocyte and CD4/CD8, serum immunoglobulin A (IgA), IgG, IgM, complement C3 and C4, interleukin (IL)-2, IL-4, IL-10, IL-12, tumor necrosis factor (TNF)-, and interferon (IFN)- were measured and statistically analyzed. Results: The LCT and control groups did not differ significantly at entry in terms of general features. Except for a significant increase of neutrophil number at 24 hours after the surgery in both groups (p < .01), all parameters representing the patients' immune function had no significant difference between the LCT and the control groups with respect to neutrophil and PBMC count, lymphocyte, CD4/CD8, serum IgA, IgG, IgM, complement C3, C4, IL-2, IL-4, IL-10, IL-12, TNF-, and IFN- (p > .05, respectively) 24 hours before the operation, and 24 hours and 120 hours after the operation. Conclusions: The regimens of LCT administration may have diverse effects on human immune function in different patient populations. However, LCT emulsion at an appropriate dose and infusion speed does not alter human immune function of adult patients undergoing moderate gastrointestinal surgery.

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