Journal of Parenteral and Enteral Nutrition

 

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Journal of Parenteral and Enteral Nutrition, Vol. 31, No. 1, 26-31 (2007)
DOI: 10.1177/014860710703100126

Original Communications

Does Glutamine Supplementation Decrease the Response of Muscle Glutamine Synthesis to Fasting in Muscle in Adult and Very Old Rats?

Michelle Mignon, Loïc Lêvêque, Emilie Bonnel and Dominique Meynial-Denis, PhD

From the Human Nutrition Unit, St Genes-Champanelle, France; and the Human Nutrition Research Center (CRNH) of Clermont-Ferrand, France

Correspondence: Dominique Meynial-Denis, PhD, Human Nutrition Unit, INRA and Human Nutrition Research Center, Theix 63122, St Genes-Champanelle, France. Electronic mail may be sent to dominique.meynial{at}clermont.inra.fr.

Background: Glutamine synthetase (GS), a key enzyme in the production of glutamine, is preserved in rat skeletal muscle during aging but is increased with advanced age in vivo. The aim of this study was to determine whether glutamine supplementation affects up-regulation of GS by fasting in vivo in adult and very old female rats. Methods: Muscle GS activities were assessed in 5-day-fasted female Wistar adult (6 months) and very old (27 months) rats refed and supplemented with glutamine or other amino acids (alanine or glycine). Fed rats were used to investigate the possible effect of glutamine supplementation in the fed state. Results: After 5 days' fasting, the up-regulated GS activity was decreased whatever the type of amino acid supplementation (glutamine, alanine, and glycine) in adults, whereas it was only decreased by glutamine supplementation in very old rats). In the fed state, no effect of glutamine supplementation was observed even if GS activity remained up-regulated whatever the age and the period of supplementation. Conclusions: These results confirm that glutamine has a specific role in very old rats. The up-regulated GS activity was decreased by an exogenous supply of glutamine only if intramuscular glutamine was depleted; this was confirmed by studies in the fed state. The up-regulated GS activity in both fed and fasted rats may be associated with increased glutamine requirements in the whole body.


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Home page
 JPEN J Parenter Enteral NutrHome page
M. Mignon, A.-M. Beaufrere, L. Combaret, and D. Meynial-Denis
Does Long-Term Intermittent Treatment With Glutamine Improve the Well-being of Fed and Fasted Very Old Rats?
JPEN J Parenter Enteral Nutr, November 1, 2007; 31(6): 456 - 462.
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