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5-Fluorouracil Infusion Reduces Gut-Associated Lymphoid Tissue Cell Number and Mucosal Immunoglobulin A Levels

Hidetoshi Nagayoshi, MD^*, Kazuhiko Fukatsu, MD, Chikara Ueno, MD^*, Etsuko Hara, MT, Yoshinori Maeshima, MD^*, Jiro Omata, MD^*, Hoshio Hiraide, MD and Hidetaka Mochizuki, MD^*

From the ^* Department of Surgery I, National Defense Medical College, and the Division of Basic Traumatology, National Defense Medical College Research Institute, Saitama, Japan

Correspondence: Kazuhiko Fukatsu, MD, Division of Basic Traumatology, National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa, Saitama, Japan 359-8513. Electronic mail may be sent to fukatsu{at}ndmc.ac.jp.

Background: Anticancer drugs have been demonstrated to affect gut mucosal morphology and cause gastrointestinal symptoms. We hypothesized that even small doses of 5-fluorouracil (5-FU) would reduce gut-associated lymphoid tissue (GALT) mass and function. Methods: Mice underwent IV cannulation and received continuous infusion of normal saline or 10 mg/kg of 5-FU for 5 days. GALT cell numbers, phenotypes, and mucosal immunoglobulin A (IgA) levels were measured. Results: During the infusion, there were no significant differences in food intake or body weight change between the 2 groups. Cell yields from the intraepithelial space and lamina propria of the small intestine were lower in the 5-FU than the control group. The lamina propria CD4/CD8 ratio was reduced in the 5-FU compared with the control group. Intestinal and respiratory tract IgA levels were lower in the 5-FU than in the control group. Conclusions: A small dose of 5-FU reduces GALT cell number and mucosal IgA levels, regardless of food intake.

Journal of Parenteral and Enteral Nutrition, Vol. 29, No. 6, 395-400 (2005)
DOI: 10.1177/0148607105029006395


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