Journal of Parenteral and Enteral Nutrition

 

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Journal of Parenteral and Enteral Nutrition, Vol. 29, No. 4 suppl, S166-S172 (2005)
DOI: 10.1177/01486071050290S4S166
© 2005 The American Society for Parenteral and Enteral Nutrition

Presentations

The Use of Enteral Nutrition in the Management of Crohn's Disease in Adults

X. Dray, MD* and Phillipe Marteau, MD, PhD{dagger}

From the * Service d'Hépato-Gastroentérologie et Assistance Nutritive, Hôpital Lariboisière, Assistance Publique des Hôpitaux de Paris, France; and the {dagger} Service de Gastroentérologie, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, France

Correspondence: Philippe Marteau, MD, PhD, Service d'hépato-gastroentérologie, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75908 Paris cedex 15, France. Electronic mail may be sent to philippe.marteau{at}egp.ap-hop-paris.fr.

Crohn's disease is a chronic, relapsing disease and none of the treatments developed so far can cure it. Artificial nutrition is effective to both treat malnutrition when present and induce remission. However, striking advances in anti-inflammatory and immunomodulating therapies (including infliximab) and low compliance to treatment in the first trials have limited its place in the management of adults to drug-resistant patients. Randomized controlled trials show that artificial nutrition is effective in >50% of the cases in this selected population. Significant progress has recently been made to improve the palatability (and thus acceptability) of some enteral solutions, which can be consumed by the oral route and as pharmaconutrition. We reviewed the literature on enteral nutrition in adults with Crohn's disease. We present herein the results of the studies performed with antioxidants, glutamine, short-chain fatty acids, prebiotics, probiotics, low microparticle diets, and a TGFβ2 enriched formulation.

 

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