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Journal of Parenteral and Enteral Nutrition
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*Crohn's Disease
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Presentations

The Anti-Inflammatory Effects of Enteral Nutrition

Ian R. Sanderson, MD and Nicholas M. Croft, MBBS, PhD

Centre for Adult & Pediatric Gastroenterology, Institute of Cell and Molecular Science, University of London, United Kingdom

Correspondence: Prof. I. R. Sanderson, Adult and Paediatric Gastroenterology, Institute of Cell and Molecular Science, Barts and The London, Turner Street, London. E1 2AD, UK. Electronic mail may be sent to i.r.sanderson{at}qmul.ac.uk.

Enteral nutrition has a positive effect on growth in children with active Crohn's disease. The question arises: is this is due only to improved nutrition? Enteral formulas may also directly reduce inflammation, lowering the expression of cytokines like interleukin (IL)-6 that inhibit growth. Four lines of evidence support the hypothesis that enteral formulas directly lessen inflammation: enteral nutrition directly affects the inflamed intestine; changes in inflammatory markers precede repletion of nutrition status; molecular pathways exist linking changes in luminal contents to the expression of class II MHC genes in intestinal epithelium in animal studies; and enteral formulas have a direct effect on cytokine expression by intestinal epithelial cells.

 

Discussion

Journal of Parenteral and Enteral Nutrition, Vol. 29, No. 4 suppl, S134-S140 (2005)
DOI: 10.1177/01486071050290S4S134
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