This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Senkal, M. Articles by Stehle, P. Search for Related Content PubMed PubMed Citation Articles by Senkal, M. Articles by Stehle, P. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Dietary Fats Social Bookmarking                         What's this?

Preoperative Oral Supplementation with Long-Chain -3 Fatty Acids Beneficially Alters Phospholipid Fatty Acid Patterns in Liver, Gut Mucosa, and Tumor Tissue

Metin Senkal, MD^*, Rolf Haaker, MD^*, Jakob Linseisen, PhD, Günther Wolfram, MD, Heinz-Herbert Homann, MD^* and Peter Stehle, PhD^¶

From the ^* Department of Surgery, St. Josef Hospital, Ruhr University, Bochum, Germany; the German Cancer Research Center, Heidelberg, Germany; the Institute for Nutrition Science, Technical University Munich, Freising, Germany; and the^¶ Department of Nutrition Science, University of Bonn, Bonn, Germany

Correspondence: Metin Senkal, MD, Department of Surgery, Marienhospital Witten, Marienplatz 2, 58452 Witten, Germany. Electronic mail may be sent to senkal{at}marien-hospital-witten.de.

Background: The uptake of -3 polyunsaturated fatty acids (PUFAs) into the liver, gut mucosa, and tumor tissue and plasma levels after preoperative administration of supplemented enteral nutrition was investigated in patients with malignancies of the upper gastrointestinal tract. The objective of the study was to evaluate the incorporation of preoperatively administrated PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) into cell phospholipids. Methods: Patients undergoing major gastrointestinal surgery (n = 40) were prospectively randomized to receive a PUFA-supplemented liquid oral diet 5 days preoperatively or an isocaloric control diet. The planned diet intake was 1000 mL/d providing 3.7 g of PUFA. The diet was given in addition to the usual hospital diet. The phospholipid fractions in plasma were analyzed on the day of surgery. Tissue samples of liver, gut mucosa (small intestine), and tumor were taken during surgery and homogenized. EPA and DHA content was analyzed using liquid gas chromatography. Results: Both patient groups (PUFA group: n = 20; control group: n = 20) were similar in age, weight, and surgical procedures. As compared with the control group, the PUFA group had significantly increased levels of EPA in liver tissue (0.4 vs 1.3 weight %), gut mucosa (0.3 vs 1.0 weight %), and tumor tissue (0.3 vs 0.8 weight %). Also, the DHA levels in the PUFA group were significantly higher than the control group: liver tissue (4.1 vs 7.5 weight %), gut mucosa (2.1 vs 3.7 weight %) and tumor tissue (1.9 vs 4.2 weight %). Conclusions: This study suggests that administration of PUFA-enriched diets leads to increased incorporation of EPA and DHA not only in liver and gut mucosa tissue, but also in tumor tissue in patients with solid gastrointestinal tumors. Thus, preoperative administration of oral PUFA-enriched diets could have an impact on the postoperative inflammatory response after major abdominal surgery.

Journal of Parenteral and Enteral Nutrition, Vol. 29, No. 4, 236-240 (2005)
DOI: 10.1177/0148607105029004236


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				Y. Maeshima, K. Fukatsu, T. Moriya, F. Ikezawa, C. Ueno, D. Saitoh, and H. Mochizuki Influence of Adding Fish Oil to Parenteral Nutrition on Gut-Associated Lymphoid Tissue JPEN J Parenter Enteral Nutr, September 1, 2007; 31(5): 416 - 422. [Abstract] [Full Text] [PDF]