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Standard Equations Are Not Accurate in Assessing Resting Energy Expenditure in Patients With Amyotrophic Lateral Sclerosis

Michael S. Sherman, MD^*, Ajay Pillai, MD^*, Ann Jackson, RD, CNSD and Terry Heiman-Patterson, MD

From the ^* Division of Pulmonary and Critical Care Medicine and the Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania; and the Department of Nutrition Services, Hahnemann University Hospital, Philadelphia, Pennsylvania

Correspondence: Michael S. Sherman, MD, The Division of Pulmonary and Critical Care Medicine, Drexel University College of Medicine, Mailstop 107, 245 North 15^th Street, Philadelphia, PA 19102-1192. Electronic mail may be sent to michael.sherman{at}drexel.edu.

Objective: To assess the utility of standard equations for calculating caloric requirements in patients with amyotrophic lateral sclerosis (ALS). Background: Malnutrition substantially increases the risk of death in ALS. Weight loss can be stabilized and survival prolonged with early gastrostomy feeding. However the use of standard nutrition equations has not been validated in this population. We therefore compared measured caloric expenditure to 2 predictive equations in patients with varying stages of ALS. Methods: Thirty-four patients were studied. Caloric expenditure and respiratory quotient (R) were measured using indirect calorimetry. Results were compared with the Harris-Benedict equation. Results: The prediction error for the Harris-Benedict equation was 18.6 + 14.9%. Limits of agreement showed this equation could overestimate caloric expenditure by 591 kcal/d and underestimate requirements by 677 kcal/d. R was >0.86 in 11 patients, suggesting overfeeding, and <0.8 in 15 patients, suggesting underfeeding. The difference between predicted and measured caloric expenditure did not correlate with disease severity, disease duration, or body mass index. Mechanically ventilated patients had higher than predicted energy expenditure. Conclusions: We found that standard equations used to calculate energy expenditure were not valid for patients with ALS. Moreover, the majority of our patients were either overfed or underfed. As underfeeding can cause diaphragm impairment, and over-feeding can increase ventilatory load, indirect calorimetry should be considered in ALS patients to determine optimal caloric requirement.

Journal of Parenteral and Enteral Nutrition, Vol. 28, No. 6, 442-446 (2004)
DOI: 10.1177/0148607104028006442


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