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Protein Energy Supplements in Unwell Elderly Patients—A Randomized Controlled Trial

Victoria Infirmary, South Glasgow University Hospitals NHS Trust, jan.potter{at}guic.scot.nhs.uk

Margaret A. Roberts, MD

Victoria Infirmary, South Glasgow University Hospitals NHS Trust

John H. McColl, MSc

Department of Statistics, University of Glasgow, Scotland

John J. Reilly, PhD

Department of Human Nutrition, University of Glasgow, Scotland

Background: To determine whether oral protein energy supplements, prescribed during hospitalization to elderly medical admissions, affect nutritional status and if baseline nutritional state influences this status. We also considered the effects on mortality, length of hospital stay, functional recovery, and institutionalization. Methods: A prospective randomized controlled trial with no placebo. Consenting patients were stratified in 3 nutritional categories, and patients from each stratum were randomized into treatment or control. Observers were blinded to randomization. The participants were emergency admissions from home to a Medicine for the Elderly Unit in a Scottish hospital. The inclusion criteria were as follows: no known malignancy, the ability to swallow, and nonobesity (BMI < 75th percentile). The intervention was a prescription of 120 mL sip feed, 3 times daily (540 kcal, 22.5 g protein per day) throughout hospitalization, using the medicine prescription chart. The trial was powered to detect change in mean percentage weight. The following outcomes were also considered: anthropometry; mortality, length of hospital stay, functional recovery, and rates of institutionalization. Results: Included in the trial were 381 patients. Nutritional supplementation was associated with significantly better energy intake (p = .001) and weight gain (p = .003) pooled across all nutritional categories. In the most poorly nourished patients, the intervention was associated with reduced mortality (5/34 versus 14/40, p < .05) and more patients improved functionally (17/25 versus 11/28, p < .04). Overall mortality results were 21/186 versus 33/195, odds ratio (OR) 0.62, 95% confidence interval (CI) 0.35, 1.13. Conclusions: Prescribing sip feed supplements in the medicine prescription chart during hospital stay reduces weight loss. Our data also support other evidence for a reduction in mortality noted in elderly patients on nutritional supplementation. There were suggestions of other clinical benefits. (Journal of Parenteral and Enteral Nutrition 25:323-329, 2001)

Journal of Parenteral and Enteral Nutrition, Vol. 25, No. 6, 323-329 (2001)
DOI: 10.1177/0148607101025006323


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