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Nutrient Support in Hematopoietic Cell Transplantation

Clinical Nutrition, Children's Hospital and Regional Medical Center, plenss{at}chmc.org

Barbara Bruemmer, PhD, RD, CD

Interdisciplinary Graduate Program in Nutritional Sciences, University of Washington

Saundra N. Aker, RD, CD

Interdisciplinary Graduate Program in Nutritional Sciences, University of Washington, Nutrition and Patient Food Services, Seattle Cancer Care Alliance, Department of Biobehavorial Nursing and Health Systems, University of Washington

George B. McDonald, MD

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Division of Gastroenterology, University of Washington School of Medicine, Seattle, Washington

High-dose cytoreduction and hematopoietic stem cell infusion form the basis for treatment of hematologic cancers, defects or failure of hematopoiesis, and some solid tumors. As an antitumor therapy, allogeneic hematopoietic cell transplantation (HCT) is superior to autologous HCT by induction of a graft-us-tumor effect. However, recipients of allografts suffer higher transplant-related mortality owing to graft-us-host disease (GVHD). Nutrition support research must recognize that HCT is a heterogeneous modality whose short and long-term outcomes are affected by transplant type, preparative regimens, diagnosis, disease stage, age, and nutritional status. The field of HCT will diversify further as lower dose cytoreduction and mixed chimerism grafts allow expansion of the technique to older patients and to other diseases. (journal of Parenteral and Enteral Nutrition 25:219-228, 2001)

Journal of Parenteral and Enteral Nutrition, Vol. 25, No. 4, 219-228 (2001)
DOI: 10.1177/0148607101025004219


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