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Journal of Parenteral and Enteral Nutrition
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A Comparison of Renal Phosphorus Regulation in Thermally Injured and Multiple Trauma Patients Receiving Specialized Nutrition Support

Roland N. Dickerson, Pharm.D.

Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee

Jane M. Gervasio, Pharm.D.

Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee

Justin J. Sherman, Pharm.D.

Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee

Kenneth A. Kudsk, M.D.

Department of Surgery, The University of Tennessee Health Science Center, Memphis, Tennessee

William L. Hickerson, M.D.

Department of Surgery, The University of Tennessee Health Science Center, Memphis, Tennessee

Rex O. Brown, Pharm.D.

Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee

To compare phosphorus intake and renal phosphorus regulation between thermally injured patients and multiple trauma patients, 40 consecutive critically ill patients, 20 with thermal injury and 20 with multiple trauma, who required enteral tube feeding were evaluated. Phosphorus intakes were recorded for 14 days from the initiation of tube feeding which was started 1 to 3 days postinjury. Serum for determination of phosphorus concentrations was collected at days 1, 3, 7, and 14 of the study period. A 24-hour urine collection was obtained during the first and second weeks of nutrition support for urinary phosphorus excretion, fractional excretion of phosphorus, renal threshold phosphate concentration, and phosphorus clearance. Average total daily phosphorus intake during the 14-day study for thermally injured patients and multiple trauma patients was 0.99 ± 0.26 mmol/kg/d vs 0.58 ± 0.21 mmol/kg/d, respectively, p < .001. Serum phosphorus concentration on the third day of observation was significantly lower in the thermally injured group than those with multiple trauma (1.9 ± 0.8 mg/dL vs 3.0 ± 0.8 mg/dL, p ≤ .01). A trend toward hypophosphatemia in the thermally injured group persisted by the seventh day of feeding (2.7 ± 1.2 mg/dL vs 3.3 ± 0.6 mg/dL, p ≤ .04). Differences in urinary phosphorus excretion was not statistically significant between the thermally injured and multiple trauma groups (271 ± 213 mg/d vs 171 ± 181 mg/d for week 1, and 320 ± 289 mg/d vs 258 ± 184 mg/d for week 2, respectively). Urinary phosphorus clearance, fractional excretion of phosphorus, or renal threshold phosphate concentrations were also not significantly different between thermally injured and multiple trauma patients. During nutrition support, serum phosphorus concentrations are lower in thermally injured patients compared with multiple trauma patients despite receiving a significantly greater intake of phosphorus. Renal phosphorus regulation does not significantly contribute to the profound hypophosphatemia observed in thermally injured patients when compared with multiple trauma patients during nutrition support. (Journal of Parenteral and Enteral Nutrition 25:152-159, 2001)

Journal of Parenteral and Enteral Nutrition, Vol. 25, No. 3, 152-159 (2001)
DOI: 10.1177/0148607101025003152
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