This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Garcia-Lorda, P. Articles by Salas-Salvadó, J. Search for Related Content PubMed PubMed Citation Articles by Garcia-Lorda, P. Articles by Salas-Salvadó, J. Social Bookmarking                         What's this?

Cytokine-Driven Inflammatory Response Is Associated with the Hypermetabolism of AIDS Patients with Opportunistic Infections

Human Nutrition Unit, Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus

Pilar Serrano, MD

Nutrition Unit, Virgen del Rocio Hospital, Sevilla, Spain

María Jesús Jiménez-Expósito, MD

Human Nutrition Unit, Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Service of Internal Medicine, University Hospital of Sant Joan, Reus

Julia Fraile, RN

Nutrition Unit, Virgen del Rocio Hospital, Sevilla, Spain

Mónica Bulló, BSc

Human Nutrition Unit, Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus

Carlos Alonso, MD PhD

Service of Internal Medicine, University Hospital of Sant Joan, Reus

Anna Bonada, MD

Human Nutrition Unit, Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Service of Internal Medicine, University Hospital of Sant Joan, Reus

Pompeyo Viciana, MD

Service of Internal Medicine, University Hospital of Sant Joan, Reus

Pedro P. García Luna, MD, PhD

Nutrition Unit, Virgen del Rocio Hospital, Sevilla, Spain

Jordi Salas-Salvadó, MD, PhD

Human Nutrition Unit, Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Service of Internal Medicine, University Hospital of Sant Joan, Reus, jss{at}fmcs.urv.es

Background: To assess a possible role of systemic inflammation in the resting metabolic response in AIDS patients with active secondary infections. Methods: Fifty-two patients with AIDS-defined criteria and concomitant active infections and 19 healthy subjects were studied. Measurements were as follows: body composition assessed by bioelectrical impedance; resting energy expenditure (REE) by 30-minute indirect calorimetry; cytokine concentrations (IL-6, IFN, TNF, sTNF-R1) by ELISA; C-reactive protein (CRP), erythrocyte sedimentation rate, fibrinogen, and nutritional parameters by standard techniques. Results: REE adjusted for fat-free mass (REE _FFM) was significantly increased in AIDS patients despite 39% of them not being hypermetabolic. The patients were undernourished and were found to have increased levels of acute-phase proteins and increased concentrations of IL-6 and sTNF-R1 relative to controls. REE parameters were positively related to CRP, ESR, ferritin, IL-6, and sTNF-R1 and negatively related to albumin, prealbumin, and transferrin. CRP was an independent predictor of REE_FFM in AIDS patients and explained 25% of its variability. Patients with severe inflammation (CRP 37 mg/dL) were significantly hypermetabolic with respect to patients without inflammation (CRP < 6 mg/dL) and had higher levels of IL-6 and sTNF-R1 and lower levels of albumin and prealbumin. Although no significant differences were observed with respect to the infection type, patients with tuberculosis and Pneumocystis carinii infections had higher resting metabolic and inflammatory responses, whereas patients with recurrent bacterial pneumonia were normometabolic and had lower levels of inflammatory markers. Conclusions: Resting hypermetabolism observed in AIDS patients with concurrent active infections is related to the presence and severity of systemic cytokine-driven inflammatory response, which could reflect the type of secondary infection. (Journal of Parenteral and Enteral Nutrition 24:317-322, 2000)

Journal of Parenteral and Enteral Nutrition, Vol. 24, No. 6, 317-322 (2000)
DOI: 10.1177/0148607100024006317


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. A. Kamimura, S. A. Draibe, M. A. Dalboni, M. Cendoroglo, C. M. Avesani, S. R. Manfredi, M. E. F. Canziani, and L. Cuppari Serum and cellular interleukin-6 in haemodialysis patients: relationship with energy expenditure Nephrol. Dial. Transplant., March 1, 2007; 22(3): 839 - 844. [Abstract] [Full Text] [PDF]

				S. Utaka, C. M Avesani, S. A Draibe, M. A Kamimura, S. Andreoni, and L. Cuppari Inflammation is associated with increased energy expenditure in patients with chronic kidney disease Am. J. Clinical Nutrition, October 1, 2005; 82(4): 801 - 805. [Abstract] [Full Text] [PDF]

				M. Allon, M. Radeva, J. Bailey, S. Beddhu, D. Butterly, D. W. Coyne, T. A. Depner, J. J. Gassman, A. M. Kaufman, G. A. Kaysen, et al. The spectrum of infection-related morbidity in hospitalized haemodialysis patients Nephrol. Dial. Transplant., June 1, 2005; 20(6): 1180 - 1186. [Abstract] [Full Text] [PDF]

				M. J Batterham Investigating heterogeneity in studies of resting energy expenditure in persons with HIV/AIDS: a meta-analysis Am. J. Clinical Nutrition, March 1, 2005; 81(3): 702 - 713. [Abstract] [Full Text] [PDF]

				J. M. Hibbert, L. L. Hsu, S. J. Bhathena, I. Irune, B. Sarfo, M. S. Creary, B. E. Gee, A. I. Mohamed, I. D. Buchanan, A. Al-Mahmoud, et al. Proinflammatory Cytokines and the Hypermetabolism of Children with Sickle Cell Disease Experimental Biology and Medicine, January 1, 2005; 230(1): 68 - 74. [Abstract] [Full Text] [PDF]

				A. Yee-Moon Wang, M. Man-Mei Sea, N. Tang, J. E. Sanderson, S.-F. Lui, P. Kam-Tao Li, and J. Woo Resting Energy Expenditure and Subsequent Mortality Risk in Peritoneal Dialysis Patients J. Am. Soc. Nephrol., December 1, 2004; 15(12): 3134 - 3143. [Abstract] [Full Text] [PDF]