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Journal of Parenteral and Enteral Nutrition
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Does the Route of Feeding Modify Gastric Emptying in Rats?

Guoxiang Shi, MD, PhD

Centre de Recherche en Nutrition Humaine, CRI-INSERM 95/08 CHU Hôtel-Dieu, Nantes

Christine Cherbut, PhD

Centre de Recherche en Nutrition Humaine, CRI-INSERM 95/08 CHU Hôtel-Dieu, Nantes

Stanislas Bruley des Varannes, MD, PhD

Centre de Recherche en Nutrition Humaine, CRI-INSERM 95/08 CHU Hôtel-Dieu, Nantes

Claude Rozé, PhD

INSERM U 410, Faculté X Bichat, Paris, France

Jean Paul Galmiche, MD, FRCP

Centre de Recherche en Nutrition Humaine, CRI-INSERM 95/08 CHU Hôtel-Dieu, Nantes

Background: It has been shown that the pattern of previous nutrient intake can influence gastric emptying. However, the effect of the absence of enteral stimulation in the setting of a normal energy supply on gastric emptying has not been examined. The aim of this study was to determine whether the absence of enteral stimulation during total parenteral nutrition (TPN) could modify gastric emptying in rats. Methods: Two experiments were performed. First, gastric emptying of a peptone meal was compared between rats receiving TPN, oral liquid diet (same solution as TPN), or regular diet (control group) for 10 days. In the second experiment, gastric emptying of two test meals (40% peptone and 25% glucose) was studied before and after rats received TPN or intragastric nutrition (same solution as TPN) for 10 to 12 days. Results: In experiment 1, gastric emptying of 40% peptone in the TPN and liquid diet groups was slower than that in the control group. This difference was significant between the TPN group and the control group (p < .01) but not between the liquid diet and control groups (p = .076). Gastric emptying of this meal in the TPN and liquid diet groups was similar. In experiment 2, no difference in gastric emptying of 40% peptone or 25% glucose was found between rats receiving TPN and those receiving intragastric nutrition for 10 to 12 days. Conclusions: The composition of diet not the route of feeding is important in the modification of gastric emptying by the pattern of previous nutrient intake. (Journal of Parenteral and Enteral Nutrition 24:164-169, 2000)

Journal of Parenteral and Enteral Nutrition, Vol. 24, No. 3, 164-169 (2000)
DOI: 10.1177/0148607100024003164
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