This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Shamir, R. Articles by Dinari, G. Search for Related Content PubMed PubMed Citation Articles by Shamir, R. Articles by Dinari, G. Social Bookmarking                         What's this?

Thiamine Deficiency in Children with Congenital Heart Disease Before and After Corrective Surgery

Division of Pediatric Gastroenterology and Nutrition, Schneider Children's Medical Center of Israel, shamirr{at}netvision.net.il

Ovdi Dagan

Pediatric Cardiac Intensive Care Unit, Schneider Children's Medical Center of Israel

Dana Abramovitch

Division of Pediatric Gastroenterology and Nutrition, Schneider Children's Medical Center of Israel

Tova Abramovitch

Division of Pediatric Gastroenterology and Nutrition, Schneider Children's Medical Center of Israel

Bernardo A. Vidne

Cardiothoracic Surgery, Beilinson Campus, Petach Tiqva, Sackler School of Medicine, Tel Aviv University, Israel

Gabriel Dinari

Division of Pediatric Gastroenterology and Nutrition

Background: Malnutrition is common in children with congenital heart disease, while thiamine deficiency (TD) is common in malnutrition, in critically ill children, and in adults with congestive heart failure treated with loop diuretics. Our goal was to determine whether children with congenital heart disease had TD and whether treatment with loop diuretics is related to TD in these patients. Methods: Twelve children with ventricular septal defect (VSD) treated with furosemide, and 10 children with tetralogy of Fallot (TOF) referred for corrective surgery were consecutively enrolled into a prospective study. Data were collected 24 hours before surgery and 5 days after surgery for nutrition evaluation, medications used, anthropometric measurements, and laboratory markers of malnutrition. Thiamine and pyridoxine deficiencies were evaluated using activated enzyme assays. Results: Seven children (32% of patients) did not meet the recommended daily allowance (RDA) for calories and 18% of patients did not meet the RDA for thiamine intake. Anthropometric measurements were low in both groups, more so in those with VSD, although the difference did not reach statistical significance. Overall, 18% (1/12 with VSD and 3/10 with TOF) of children with congenital heart disease had thiamine deficiency before surgery. Three of the four children with TD had adequate intake of thiamine. Six children (27%) had TD 5 days postsurgery (3 children with VSD and 3 children with TOF). Conclusions: TD is common in children with congenital heart disease (CHD) referred for corrective surgery both before and after surgery. Our results suggest that neither diuretic treatment nor malnutrition can fully explain the development of TD in these children. (Journal of Parenteral and Enteral Nutrition 24:154-158, 2000)

Journal of Parenteral and Enteral Nutrition, Vol. 24, No. 3, 154-158 (2000)
DOI: 10.1177/0148607100024003154


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. Masumoto, G. Esumi, R. Teshiba, K. Nagata, T. Nakatsuji, Y. Nishimoto, S. Ieiri, N. Kinukawa, and T. Taguchi Need for Thiamine in Peripheral Parenteral Nutrition After Abdominal Surgery in Children JPEN J Parenter Enteral Nutr, July 1, 2009; 33(4): 417 - 422. [Abstract] [Full Text] [PDF]