This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Wright, D. H. Articles by Rotschafer, J. C. Search for Related Content PubMed PubMed Citation Articles by Wright, D. H. Articles by Rotschafer, J. C. Social Bookmarking                         What's this?

Decreased In Vitro Fluoroquinolone Concentrations After Admixture With an Enteral Feeding Formulation

Regions Hospital, Clinical Pharmacy, St Paul, Minnesota, University of Minnesota, College of Pharmacy, Minneapolis

Sarah L. Pietz, BAT

Scientific Research Consortium, Inc, St Paul, Minnesota

Frank N. Konstantinides, MT, MSt

University of Minnesota, College of Pharmacy, Minneapolis, Scientific Research Consortium, Inc, St Paul, Minnesota

John C. Rotschafer, PharmD, FCCP

Regions Hospital, Clinical Pharmacy, St Paul, Minnesota, University of Minnesota, College of Pharmacy, Minneapolis

Background: The purpose of this study was to determine if mixing of fluoroquinolones with a common enteral feeding formulation, Ensure (Ross Products Division, Abbott Laboratories, Columbus, OH), would alter the measured in vitro quinolone concentrations over a 24-hour period. Methods: Tablets of ciprofloxacin (500 mg), levofloxacin (500 mg), and ofloxacin (300 mg) were crushed and mixed with 240 mL of Ensure, water and calcium chloride (500 mg/L), water and magnesium chloride (200 mg/L), water and calcium chloride and magnesium chloride, and water alone. Fluoroquinolone concentrations of the mixtures were measured, via high-performance liquid chromatography, at baseline and serially over 24 hours. Experiments were performed in duplicate, at three temperatures (5°C, 25°C, and 37°C). Results: Average decreases of 82.5% ± 1.5% for ciprofloxacin, 61.3% ± 5.2% for levofloxacin, and 45.7% ± 10.1% for ofloxacin (mean ± 95% CI) were observed in vitro for Ensure over the two experimental sets at baseline. Serial analysis revealed no further significant change in any of the quinolone concentrations over the remaining 24-hour period. No significant decrease was noted with the quinolones when mixed in water and calcium, water and magnesium, water and calcium and magnesium, or water alone. This phenomenon appears to be unaffected by time and temperature. Conclusions: These data suggest there is an immediate and significant loss of fluoroquinolone when mixed with Ensure. An explanation for the loss of fluoroquinolone remains unclear. (Journal of Parenteral and Enteral Nutrition 24:42-48, 2000)

Journal of Parenteral and Enteral Nutrition, Vol. 24, No. 1, 42-48 (2000)
DOI: 10.1177/014860710002400142


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				N. T. Williams Medication administration through enteral feeding tubes Am. J. Health Syst. Pharm., December 15, 2008; 65(24): 2347 - 2357. [Abstract] [Full Text] [PDF]

				E. M. Graffunder and R. A. Venezia Risk factors associated with nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection including previous use of antimicrobials J. Antimicrob. Chemother., June 1, 2002; 49(6): 999 - 1005. [Abstract] [Full Text] [PDF]