This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Ziegler, T. R. Articles by Leader, L. M. Search for Related Content PubMed PubMed Citation Articles by Ziegler, T. R. Articles by Leader, L. M. Social Bookmarking                         What's this?

Interactions Between Nutrients and Peptide Growth Factors in Intestinal Growth, Repair, and Function

Department of Medicine, Emory University School of Medicine, Atlanta, Georgia

Concepción F. Estivariz, MD

Department of Medicine, Emory University School of Medicine, Atlanta, Georgia

Carolyn R. Jonas, RD, MS

Department of Medicine, Emory University School of Medicine, Atlanta, Georgia

Li H. Gu, MD

Department of Medicine, Emory University School of Medicine, Atlanta, Georgia

Dean P. Jones, PhD

Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia

Lorraine M. Leader, MD

Divisions of Endocrinology/Metabolism and Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia

Several lines of evidence demonstrate that general nutritional status, specific nutrients (eg, zinc, glutamine), and certain trophic growth factors (eg, growth hormone, insulin-like growth factor I, keratinocyte growth factor, and glucagon-like peptide-2) have important interactions relevant for intestinal growth and function. Adequate nutritional status is critical for endogenous growth factor synthesis in the gut and other tissues and is an important mediator of organ responsiveness to exogenous growth factor administration. Both endogenously synthesized and exogenously administered growth factors upregulate nutrient uptake and utilization by gut mucosa, skeletal muscle, and other organs. Emerging data from both animal and human studies indicate that combinations of selected growth factors and specific nutrients may improve the growth, adaptation, and repair of the intestinal mucosa. Additional studies to determine basic mechanisms of nutrient—growth factor interactions and the safety and efficacy of treatment with combinations of specific nutrients and recombinant growth factors are needed. Results of these investigations should define new methods for support of the intestinal tract during short bowel syndrome (SBS), catabolic illness, and malnutrition. (Journal of Parenteral and Enteral Nutrition 23:S174-S183, 1999)

Journal of Parenteral and Enteral Nutrition, Vol. 23, No. 6 Suppl, S174-S183 (1999)
DOI: 10.1177/014860719902300602


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				N. R. Parekh and E. Steiger Criteria for the Use of Recombinant Human Growth Hormone in Short Bowel Syndrome Nutr Clin Pract, October 1, 2005; 20(5): 503 - 508. [Abstract] [Full Text] [PDF]