This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hasebe, M. Articles by Ueda, Y. Search for Related Content PubMed PubMed Citation Articles by Hasebe, M. Articles by Ueda, Y. Social Bookmarking                         What's this?

Glutamate in Enteral Nutrition: Can Glutamate Replace Glutamine in Supplementation to Enteral Nutrition in Burned Rats?

Trauma and Critical Care Center, Teikyo University School of Medicine

Hiromasa Suzuki, MD

Trauma and Critical Care Center, Teikyo University School of Medicine

Eigo Mori, PhD

Trauma and Critical Care Center, Teikyo University School of Medicine

Junko Furukawa, BS

Trauma and Critical Care Center, Teikyo University School of Medicine

Kunio Kobayashi, MD

Trauma and Critical Care Center, Teikyo University School of Medicine

Yoshitsugu Ueda, MS

Terumo Corporation, Tokyo, Japan

Background: Glutamine (GLN) plays many important roles for the enterocytes in health and disease, but no liquid enteral products contain GLN because of its instability. We hypothesized that glutamate (GLU) may replace GLN in supplementation to an enteral diet, and compared the metabolic effect of GLU and GLN on the gut to each other. Methods: Rats suffering from a 30% burn received an enteral diet containing 30% GLU (m/w to total amino acids; GLU group), 30% GLN (GLN group), or a standard amino acid formula (CTR group). After a 64-hour feeding period, the small intestine and the portal and arterial blood were harvested to observe portal and arterial amino acid levels, and glutaminase activity and glutathione in the jejunal mucosa. In another study, ³H uptake into the mucosal protein was examined after a massive dose injection of ³H-phenylalanine. Results: Alanine, a product of GLN or GLU catabolism, significantly increased in the portal blood of the GLU group compared with the GLN group. In the gut mucosa of the GLU group, ³H uptake into protein and total glutathione were higher than those of other two groups. GLN did not elevate the glutaminase activity. Arterial GLU levels increased in the GLU group, however remained within safety limits. Conclusions: Enterally delivered GLU may be a preferable fuel for the enterocytes and enhance the mucosal protein synthesis. GLU probably can substitute for GLN in supplementation to an enteral diet regarding many roles GLN plays in the intestinal mucosa under stress situations. (Journal of Parenteral and Enteral Nutrition 23:S78-S82, 1999)

Journal of Parenteral and Enteral Nutrition, Vol. 23, No. 5 Suppl, S78-S82 (1999)
DOI: 10.1177/014860719902300520


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. Holecek, T. Muthny, M. Kovarik, and L. Sispera Simultaneous Infusion of Glutamine and Branched-Chain Amino Acids (BCAA) to Septic Rats Does Not Have More Favorable Effect on Protein Synthesis in Muscle, Liver, and Small Intestine Than Separate Infusions JPEN J Parenter Enteral Nutr, November 1, 2006; 30(6): 467 - 473. [Abstract] [Full Text] [PDF]