This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kim, J. Articles by Heymsfield, S. B. Search for Related Content PubMed PubMed Citation Articles by Kim, J. Articles by Heymsfield, S. B. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information AIDS Hazardous Substances DB CHLORINE POTASSIUM SODIUM SODIUM BROMIDE TRITIUM Social Bookmarking                         What's this?

Extracellular Water: Sodium Bromide Dilution Estimates Compared With Other Markers in Patients With Acquired Immunodeficiency Syndrome

Obesity Research Center and Body Composition Unit, Biobehavioral Studies, Teachers College, Columbia University, New York

ZiMian Wang, PhD

Obesity Research Center and Body Composition Unit

Dympna Gallagher, EdD

Obesity Research Center and Body Composition Unit

Donald P. Kotler, MD

Division of Gastroenterology, St Luke's/Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York

Kaizong Ma, MS

Obesity Research Center and Body Composition Unit

Steven B. Heymsfield, MD

Obesity Research Center and Body Composition Unit

Extracellular fluid and closely related extracellular water (ECW) provide information on nutritional status in health and disease. Although various methods exist for ECW determination, little is known about their comparability in patients with wasting diseases such as acquired immunodeficiency syndrome (AIDS). One practical method, the dilution of sodium bromide (NaBr), is used widely in clinical research, although its relationship to other ECW markers has not been well characterized. The present study sought to compare ECW estimates as determined by NaBr and three other methods in 11 male patients with AIDS (mean ± SD; age, 44 ± 12 years; body weight, 64.5 ± 8.8 kg; and height, 172 ± 4 cm) . ECW volumes were determined from NaBr dilution, total body chlorine (TBC1) by delayed -neutron activation analysis, total body water (TBW) by tritium dilution combined with total body potassium (TBK) by whole body ⁴⁰K counting, and radioactive sulfate dilution ( ³⁵SO₄). All correlations between the NaBr method and other methods were statistically significant (NaBr vs TBC1 [r = .91; p < .001]; vs TBW/TBK [r = .76; p < .01]; and vs ³⁵SO₄ [r = .89; p < .001]). As expected from previous studies, ECW (L) derived by NaBr provided a group mean (15.1 ± 2.2 L) similar to the TBC1 method (15.4 ± 1.7 L; p = .32), a significantly smaller ECW than by the TBW/TBK method (18.6 ± 3.4 L; p = .0004) , and a significantly larger ECW than by ³⁵SO₄ method (13.3 ± 3.0 L; p = .002). Estimating ECW by NaBr dilution was comparable with other research-based ECW methods and, thus, offers a practical alternative for evaluating ECW in patients with AIDS. (Journal of Parenteral and Enteral Nutrition 23:61-66, 1999)

Journal of Parenteral and Enteral Nutrition, Vol. 23, No. 2, 61-66 (1999)
DOI: 10.1177/014860719902300261


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. M Silva, S. B Heymsfield, D. Gallagher, J. Albu, X. F Pi-Sunyer, R. N Pierson Jr, J. Wang, S. Heshka, L. B Sardinha, and Z. Wang Evaluation of between-methods agreement of extracellular water measurements in adults and children Am. J. Clinical Nutrition, August 1, 2008; 88(2): 315 - 323. [Abstract] [Full Text] [PDF]

				G. A Kaysen, F. Zhu, S. Sarkar, S. B Heymsfield, J. Wong, C. Kaitwatcharachai, M. K Kuhlmann, and N. W Levin Estimation of total-body and limb muscle mass in hemodialysis patients by using multifrequency bioimpedance spectroscopy Am. J. Clinical Nutrition, November 1, 2005; 82(5): 988 - 995. [Abstract] [Full Text] [PDF]

				M.-P. St-Onge, J. Wang, W. Shen, Z. Wang, D. B. Allison, S. Heshka, R. N. Pierson Jr., and S. B. Heymsfield Dual-Energy X-Ray Absorptiometry-Measured Lean Soft Tissue Mass: Differing Relation to Body Cell Mass Across the Adult Life Span J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2004; 59(8): B796 - B800. [Abstract] [Full Text] [PDF]

				M. Bruehlmeier, U. Roelcke, P. Blauenstein, J. Missimer, P. A. Schubiger, J. Th. Locher, R. Pellikka, and S. M. Ametamey Measurement of the Extracellular Space in Brain Tumors Using 76Br-Bromide and PET J. Nucl. Med., August 1, 2003; 44(8): 1210 - 1218. [Abstract] [Full Text] [PDF]

				P. Ritz Bioelectrical Impedance Analysis Estimation of Water Compartments in Elderly Diseased Patients: The Source Study J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2001; 56(6): M344 - M348. [Abstract] [Full Text] [PDF]

				K. J Ellis Reply to K de Meer Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1617 - 1618. [Full Text] [PDF]