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Journal of Parenteral and Enteral Nutrition
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Protein Metabolism in Rats During Long-Term Dietary Restriction: Influence of Aging

Catherine Felgines, PharmD, PhD

Laboratory of Biochemistry, Molecular Biology and Nutrition, Pharmacy School, EA 2146, and CRNH, Clermont-Ferrand, France

Chantal Savanovitch, MS

Laboratory of Biochemistry, Molecular Biology and Nutrition, Pharmacy School, EA 2146, and CRNH, Clermont-Ferrand, France

Marie-Chantal Farges, PhD

Laboratory of Biochemistry, Molecular Biology and Nutrition, Pharmacy School, EA 2146, and CRNH, Clermont-Ferrand, France

Luc Cynober, PharmD, PhD

Laboratory of Biochemistry, Molecular Biology and Nutrition, Pharmacy School, EA 2146, and CRNH, Clermont-Ferrand, France

Marie-Paule Vasson, PharmD, PhD

Laboratory of Biochemistry, Molecular Biology and Nutrition, Pharmacy School, EA 2146, and CRNH, Clermont-Ferrand, France

Background: Protein depletion is frequent in the elderly, but the underlying mechanisms are not yet fully understood. In particular, it is unknown whether there is a defect of adaptation to a restriction of food intake in the elderly. This study was performed to compare the effects of 6-week dietary restriction (DR) on protein metabolism in both adult and aged rats. Methods: Adult (3-month-old) and aged (22-month-old) rats were acclimatized for 2 weeks and then fed a standard diet for 6 weeks, either ad libitum (control adult [CAdult] and aged [ CAged] rats) or with only 50% of the average intake of the second week of acclimatization (restricted adult [RAdult] and aged [RAged] rats). Protein metabolism, in terms of tissue protein content, nitrogen balance, and 3-methylhistidine (3-MH) urinary excretion, was evaluated. Results: CAdult rats gained 30.4% of initial weight, whereas the body weight (BW) of CAged rats was maintained. DR induced a rapid decrease in BW during the first 2 weeks in RAdult rats, but afterward BW remained stable. In R Aged rats, BW loss was linear during the 6 weeks and significantly higher than for RAdult rats (p < .01). In both restricted groups, muscle protein content was moderately affected by DR, whereas DR induced a marked decrease in visceral protein content. Nitrogen balance was decreased by DR but stayed positive in RAdult rats, whereas it became null in RAged rats. Conclusions: In terms of protein metabolism, aged rats adapted less efficiently than adult rats to a long-term dietary restriction. (Journal of Parenteral and Enteral Nutrition 23:32-37,1999)

Journal of Parenteral and Enteral Nutrition, Vol. 23, No. 1, 32-37 (1999)
DOI: 10.1177/014860719902300132
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