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Enteral Glutamine Supplementation for Very-Low-Birth-Weight Infants Decreases Hospital Costs

Clinical Research Center, University of Florida, Gainesville

Dan Bowling, Mstat

Clinical Research Center, University of Florida, Gainesville

Juan C. Roig, MD

Department of Pediatrics, University of Florida, Gainesville

Nancy Auestad, PhD

Ross Products Division, Abbott Laboratories, Columbus, Ohio

Josef Neu, MD

Department of Pediatrics, University of Florida, Gainesville

Background: There is growing evidence that glutamine may be a conditionally essential amino acid for critically ill patients, including preterm infants cared for in neonatal intensive care units (NICUs). In a randomized study of 68 very-low-birth-weight (VLBW) infants, we found evidence of lower morbidity in a group fed glutamine-supplemented preterm infant formula from postnatal day 3 to day 30 than in a group fed a standard formula. We report here the effects of the glutamine supplementation on hospital costs in these infants. Methods: The costs were analyzed by log-rank tests and Kaplan-Meier plots. Results: The median costs for hospitalization, radiology, pharmacy, laboratory, and the NICU, and the median number of utilization units were reduced with glutamine supplementation. Conclusions: This study provides the first evidence for decreased hospital costs in VLBW neonates who receive enteral glutamine supplementation. (Journal of Parenteral and Enteral Nutrition 22:352-356, 1998)

Journal of Parenteral and Enteral Nutrition, Vol. 22, No. 6, 352-356 (1998)
DOI: 10.1177/0148607198022006352


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