This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Mccarter, M. D. Articles by Daly, J. M. Search for Related Content PubMed PubMed Citation Articles by Mccarter, M. D. Articles by Daly, J. M. Social Bookmarking                         What's this?

Preoperative Oral Supplement With Immunonutrients in Cancer Patients

Department of Surgery, New York Hospital-Cornell University Medical College, New York

Oreste D. Gentilini, MD

Department of Surgery, New York Hospital-Cornell University Medical College, New York

Maureen E. Gomez, RN

Department of Surgery, New York Hospital-Cornell University Medical College, New York

John M. Daly, MD

Department of Surgery, New York Hospital-Cornell University Medical College, New York

Background: Early postoperative enteral nutrition with immune-enhancing supplements has helped to restore immune function and reduce infectious complications in patients with cancer undergoing major gastrointestinal operations. The aim of this study was to evaluate the effectiveness of similar supplements (containing arginine and arginine plus omega-3 fatty acids) given preoperatively for 1 week before cancer surgery. Methods: In this randomized, double-blinded study, patients scheduled to undergo elective resection of upper gastrointestinal tumors were given one of three different oral liquid supplemental diets (control, arginine, arginine plus omega-3 fatty acids) to be taken each day for 7 days before surgery. Blood samples were obtained upon enrollment, on the morning of surgery, and on postoperative day 1 for analysis of immunologic function. Results: Mean serum ornithine (a metabolite of arginine) levels were significantly higher compared with controls, but no significant increase in mean serum arginine levels was noted on the morning of surgery for those patients who received arginine as part of the supplement. In conjunction with these findings, there were no differences among groups in mean lymphocyte mitogenesis, mean peripheral blood mononuclear cell production of cytokines, or clinical outcomes. Conclusions: Use of oral liquid supplements in this fashion did not improve lymphocyte proliferation or monocyte functions in patients with cancer undergoing major surgery. (Journal of Parenteral and Enteral Nutrition 22 :206-211, 1998)

Journal of Parenteral and Enteral Nutrition, Vol. 22, No. 4, 206-211 (1998)
DOI: 10.1177/0148607198022004206


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C. H. MacLean, S. J. Newberry, W. A. Mojica, P. Khanna, A. M. Issa, M. J. Suttorp, Y.-W. Lim, S. B. Traina, L. Hilton, R. Garland, et al. Effects of Omega-3 Fatty Acids on Cancer Risk: A Systematic Review JAMA, January 25, 2006; 295(4): 403 - 415. [Abstract] [Full Text] [PDF]

				D. H. Jho, S. M. Cole, E. M. Lee, and N. J. Espat Role of Omega-3 Fatty Acid Supplementation in Inflammation and Malignancy Integr Cancer Ther, June 1, 2004; 3(2): 98 - 111. [Abstract] [PDF]

				M. A. van Bokhorst-de van der Schueren, J. J Quak, B M. E von Blomberg-van der Flier, D. J Kuik, S. I Langendoen, G. B Snow, C. J Green, and P. A. van Leeuwen Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients Am. J. Clinical Nutrition, February 1, 2001; 73(2): 323 - 332. [Abstract] [Full Text] [PDF]