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Urinary 3-Methylhistidine Excretion: Association With Total Body Skeletal Muscle Mass by Computerized Axial Tomography

Department of Medicine, Obesity Research Center, St Luke's-Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, Department of Human Nutrition and Epidemiology, Wageningen Agricultural University, Wageningen, The Netherlands

Paul Deurenberg, PHD

Department of Human Nutrition and Epidemiology, Wageningen Agricultural University, Wageningen, The Netherlands

Dwight E. Matthews, PHD

Department of Medicine, University of Vermont, Burlington

Steven B. Heymsfield, MD

Department of Medicine, Obesity Research Center, St Luke's-Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York

Background: The urinary excretion of endogenous 3-methylhistidine (3-MH) has been proposed as a predictor of skeletal muscle mass (SM). In this study, we report the relationship between 24-hour urinary 3-MH excretion and SM. Methods: Total body SM was measured by multiscan computerized axial tomography (CT) in a sample of 10 healthy adult men who followed a meat-free diet for 7 days. 3-MH was measured during the last 3 days of the meat-free diet protocol on consecutive 24-hour urine collections. Results: The 3-MH excretion was 216.3 ± 44.7 µmol/d (mean ± SD) and was found well associated with SM (in kilograms), SM = 0.0887 x 3-MH + 11.8; r = .88, p < .001. Compared with CT, the previous 3-MH-SM prediction equation suggested by Lukaski et al underestimated SM by an average of 8.9 kg in the 10 healthy men. This difference was caused by the Burkinshaw-Cohn neutron activation model, which underestimated SM and was used as the reference in the Lukaski method. Conclusions: Twenty-four-hour urinary 3-MH excretion can be applied for estimating SM in healthy adult men on a meat-free diet. (Journal of Parenteral and Enteral Nutrition 22:82-86, 1998)

Journal of Parenteral and Enteral Nutrition, Vol. 22, No. 2, 82-86 (1998)
DOI: 10.1177/014860719802200282


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