This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Medina, V. Articles by González, F. Search for Related Content PubMed PubMed Citation Articles by Medina, V. Articles by González, F. Social Bookmarking                         What's this?

Sodium Butyrate Inhibits Carcinoma Development in a 1,2-Dimethylhydrazine-Induced Rat Colon Cancer

Hospitat Universitario de Canarias, Universidad de La Laguna, Tenerife, Spain

J.J. Afonso, MD

Hospitat Universitario de Canarias, Universidad de La Laguna, Tenerife, Spain

H. Alvarez-Arguelles, MD

Hospitat Universitario de Canarias, Universidad de La Laguna, Tenerife, Spain

C. Hernández, PHD

Hospitat Universitario de Canarias, Universidad de La Laguna, Tenerife, Spain

F. González, MD

Hospitat Universitario de Canarias, Universidad de La Laguna, Tenerife, Spain

Background: Butyric acid is one of the most important by-products of dietary fiber degradation. It is an important trophic agent for the intestinal mucosa under different experimental conditions. Data obtained from several in vitro studies strongly suggest that butyrate can be a potential therapeutic agent in controlling the growth of some cancer cells. However, to date, in vivo animal studies have failed to show conclusive results. Methods: We evaluated the effects of intracecal administration of butyrate in an experimental model of colonic carcinogenesis induced by 1,2-dimethylhydrazine (DMH), administered at the site where it is naturally produced, the cecum. We studied the incidence of colon tumors and their main histologic features. Results: Direct application of sodium butyrate significantly decreased the total number of tumors and the incidence of malignancies and carcinoma in the colon. Conclusions: Butyrate may inhibit the growth of tumors induced by DMH. (Journal of Parenteral and Enteral Nutrition 22: 14-17, 1998)

Journal of Parenteral and Enteral Nutrition, Vol. 22, No. 1, 14-17 (1998)
DOI: 10.1177/014860719802200114


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				B. G. Heerdt, M. A. Houston, and L. H. Augenlicht The Intrinsic Mitochondrial Membrane Potential of Colonic Carcinoma Cells Is Linked to the Probability of Tumor Progression Cancer Res., November 1, 2005; 65(21): 9861 - 9867. [Abstract] [Full Text] [PDF]

				B. G. Heerdt, M. A. Houston, A. J. Wilson, and L. H. Augenlicht The Intrinsic Mitochondrial Membrane Potential ({Delta}{psi}m) Is Associated with Steady-State Mitochondrial Activity and the Extent to Which Colonic Epithelial Cells Undergo Butyrate-mediated Growth Arrest and Apoptosis Cancer Res., October 1, 2003; 63(19): 6311 - 6319. [Abstract] [Full Text] [PDF]

				S. Sakuma, Z.-R. Lu, B. Pecharova, P. Kopeckova, and J. Kopecek N-(2-Hydroxypropyl)methacrylamide Copolymer-9-Aminocamptothecin Conjugate: Colon-Specific Drug Delivery in Rats Journal of Bioactive and Compatible Polymers, September 1, 2002; 17(5): 305 - 319. [Abstract] [PDF]

				G. Caderni, C. Luceri, C. De Filippo, M. Salvadori, A. Giannini, L. Tessitore, and P. Dolara Slow-release pellets of sodium butyrate do not modify azoxymethane (AOM)-induced intestinal carcinogenesis in F344 rats Carcinogenesis, March 1, 2001; 22(3): 525 - 527. [Abstract] [Full Text] [PDF]

				J. T. Wu, S. Y. Archer, B. Hinnebusch, S. Meng, and R. A. Hodin Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis Am J Physiol Gastrointest Liver Physiol, March 1, 2001; 280(3): G482 - G490. [Abstract] [Full Text] [PDF]

				G. H. McIntosh, P. J. Royle, and G. Pointing Wheat Aleurone Flour Increases Cecal {beta}-Glucuronidase Activity and Butyrate Concentration and Reduces Colon Adenoma Burden in Azoxymethane-Treated Rats J. Nutr., January 1, 2001; 131(1): 127 - 131. [Abstract] [Full Text]

				G. Dongowski, A. Lorenz, and H. Anger Degradation of Pectins with Different Degrees of Esterification by Bacteroides thetaiotaomicron Isolated from Human Gut Flora Appl. Envir. Microbiol., April 1, 2000; 66(4): 1321 - 1327. [Abstract] [Full Text] [PDF]

				C. W. Compher, W. L. Frankel, J. Tazelaar, J. A. Lawson, S. McKinney, S. Segall, B. P. Kinosian, N. N. Williams, and J. L. Rombeau Wheat Bran Decreases Aberrant Crypt Foci, Preserves Normal Proliferation, and Increases Intraluminal Butyrate Levels in Experimental Colon Cancer JPEN J Parenter Enteral Nutr, September 1, 1999; 23(5): 269 - 278. [Abstract] [PDF]

				M. G. Ramos, E. A. Bambirra, J. R. Nicoli, D. C. Cara, E. C. Vieira, and J. Alvarez-Leite Protection by Short-Chain Fatty Acids against 1-beta -D-Arabinofuranosylcytosine-Induced Intestinal Lesions in Germfree Mice Antimicrob. Agents Chemother., April 1, 1999; 43(4): 950 - 953. [Abstract] [Full Text] [PDF]

				J M Mariadason, A Catto-Smith, and P R Gibson Modulation of distal colonic epithelial barrier function by dietary fibre in normal rats Gut, March 1, 1999; 44(3): 394 - 399. [Abstract] [Full Text] [PDF]