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Journal of Parenteral and Enteral Nutrition
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Comparison of Bone Marrow Toxicity of Medium-Chain and Long-Chain Triglyceride Emulsions: An In Vitro Study in Humans

Philippe Beau, MD

Gastroenterology and Nutritional Support Unit, University Hospital, Poitiers, France

Paul Régis Mannant, MD

Gastroenterology and Nutritional Support Unit, University Hospital, Poitiers, France

Daniele Pelletier

Hematology Laboratory, University Hospital, Poitiers, France

André Brizard, MD, PHD

Hematology Laboratory, University Hospital, Poitiers, France

Background: In this study, we evaluated the in vitro bone marrow toxicity of two lipid emulsions containing either long-chain triglycerides (LCT) or a mixture of medium-chain triglycerides (MCT) and LCT. Methods: Bone marrow cells were obtained from six healthy subjects and were cultured for 14 days after a 24-hour preincubation with various concentrations (from 0 to 10 mg/mL) of LCT- and LCT/MCT-based lipid emulsions. Results: Compared with controls (no preincubation with lipid emulsion), both lipid emulsions significantly inhibited by 50% to 70% colony formation of all the human bone marrow cells cultured from a triglyceride concentration of 0.5 mg/mL (p < .05). Erythroid burst-forming unit (BFU-E) formation was significantly more inhibited with LCT/MCT emulsion than with LCT emulsion (p < .05). The inhibition of granulocyte-macrophage colony-forming unit (GM-CFU) and mixed granulocyte-erythrocyte-monocytemegakaryocyte colony-forming unit (GEMM-CFU) formation did not significantly differ with the two emulsions. Conclusions: Both LCT- and LCT/MCT-based lipid emulsions strongly inhibit colony formation by human bone marrow cells. BFU-E colony formation is more sensitive to LCT/MCT inhibition than to LCT. (Journal of Parenteral and Enteral Nutrition 21:343-346, 1997)

Journal of Parenteral and Enteral Nutrition, Vol. 21, No. 6, 343-346 (1997)
DOI: 10.1177/0148607197021006343
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 International Journal of ToxicologyHome page
Caprylic/Capric Triglyceride
International Journal of Toxicology, January 1, 2003; 22(1_suppl): 4 - 5.
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