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Pentoxifylline and Thalidomide Fail to Reduce Hepatic Steatosis During Total Parenteral Nutrition and Bowel Rest in the Rat

Department of Surgery, Hebrew University Hadassah Medical School, Jerusalem, Israel

Ram M. Spira, MD

Department of Surgery, Hebrew University Hadassah Medical School, Jerusalem, Israel

Herve Bercovier, DVM

Deparmtent of Clinical Microbiology, Hebrew University Hadassah Medical School, Jerusalem, Israel

Elliot Berry, MD

Department of Nutrition, Hebrew University Hadassah Medical School, Jerusalem, Israel

Herbert R. Freund, MD

Department of Surgery, Hebrew University Hadassah Medical School, Jerusalem, Israel

Background: We suggested that the continuous translocation of endotoxin from Gram-negative bacterial overgrowth during bowel rest and total parenteral nutrition (TPN) causes the release of tumor necrosis factor (TNF), resulting in liver damage and hepatic dysfunction. Because TPN-induced hepatic steatosis was significantly reduced by the monoclonal antibodies against TNF, we attempted a more clinically applicable approach using pentoxifylline and thalidomide. Methods: A control group (group I) fed rat chow and four groups of rats receiving TPN were studied. Group II received TPN only; group III, TPN and 100 mg/kg/d pentoxifylline; group IV, TPN and 200 mg/kg/d pentoxifylline; and group V, TPN and 5 mg/kg/d thalidomide. On day 7, total liver fat was determined. Results: Bowel rest and TPN resulted in a significant (p < .0005) increase in liver fat content that was unaltered by either pentoxifylline or thalidomide. Conclusions: Our results show no role for pentoxifylline or thalidomide in reducing TPN-associated hepatic steatosis. (journal of Parenteral and Enteral Nutrition 21:233-234, 1997)

Journal of Parenteral and Enteral Nutrition, Vol. 21, No. 4, 233-234 (1997)
DOI: 10.1177/0148607197021004233


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