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Effects of Growth Hormone and Insulin-Like Growth Factor 1 (IGF-1) Treatments on the Nitrogen Metabolism and Hepatic IGF-1-Messenger RNA Expression in Postoperative Parenterally Fed Rats

Department of Surgery I, Faculty of Agriculture, University of Tokyo, Japan

Hideaki Saito, MD

Surgical Center, Faculty of Medicine, Faculty of Agriculture, University of Tokyo, Japan

Ryoji Fukushima, MD

Department of Surgery I, Faculty of Agriculture, University of Tokyo, Japan

Yojiro Hashiguchi, MD

Department of Surgery I, Faculty of Agriculture, University of Tokyo, Japan

Ming-Tsan Lin, MD

Department of Surgery I, Faculty of Agriculture, University of Tokyo, Japan

Tomomi Inoue, MD

Department of Surgery I, Faculty of Agriculture, University of Tokyo, Japan

Kazuhiko Fukatsu, MD

Department of Surgery I, Faculty of Agriculture, University of Tokyo, Japan

Tetsuichiro Muto, MD

Department of Surgery I, Faculty of Agriculture, University of Tokyo, Japan

Asako Takenaka, PHD

Laboratory of Nutritional Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Japan

Shin-Ichiro Takahashi, PHD

Laboratory of Nutritional Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Japan

Tadashi Noguchi, PHD

Laboratory of Nutritional Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Japan

Background: Few studies have made direct comparisons of the metabolic effects of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). We have assessed the dose-dependent effects of GH and IGF-1 treatments on nitrogen metabolism, intestinal structure, and hepatic IGF-1-messenger RNA (mRNA) expression in postoperative parenterally fed rats. Methods: Rats were maintained on total parenteral nutrition (TPN) for 3 days after gastrectomy. GH (0.4 or 0.8 IU/kg/d) or IGF-1 (1, 2, or 4 mg/kg/d) was infused throughout the experimental period. Anabolic effects of GH and IGF-1 were assessed by body weight change, nitrogen excretion, and whole-body protein turnover. Organ weights, intestinal structure, plasma IGF-1 levels and hepatic IGF-1-mRNA contents were also determined. Results: Both GH and IGF-1 attenuated body weight loss and nitrogen excretion and increased whole-body protein synthesis and spleen weight. These observations suggest that the anabolic effects of 1 mg/kg/d of IGF-1 were equivalent to those of 0.66 IU/kg/d of GH. IGF-1, but not GH, reduced atrophy of the intestinal mucosa. GH treatment increased hepatic IGF-1-mRNA and the plasma IGF-1 level, whereas IGF-1 treatment increased the plasma IGF-1 level with no change in the hepatic IGF-1-mRNA content. Conclusions: Administration of GH or IGF-1 attenuates catabolism after surgery. The anabolic effects of 1 mg/kg/d of IGF-1 are equivalent to those of 0.66 IU/kg/d of GH. IGF-1 reduces intestinal mucosal atrophy. GH increases hepatic IGF-1-mRNA and the plasma IGF-1 level. (Journal of Parenteral and Enteral Nutrition 20:325-331, 1996)

Journal of Parenteral and Enteral Nutrition, Vol. 20, No. 5, 325-331 (1996)
DOI: 10.1177/0148607196020005325


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