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Selenoprotein P in Patients on Home Parenteral Nutrition

Division of Gastroenterology, Medical Department A, Rigshospitaslet, Copenhagen, Denmark

Marie Persson-Moschos, MS

Department of Applied Nutrition and Food Chemistry, University of Lund, Sweden

Wenhu Huang

B. Pharm, Department of Applied Nutrition and Food Chemistry, University of Lund, Sweden

Michael Staun, MD

Division of Gastroenterology, Medical Department A, Rigshospitaslet, Copenhagen, Denmark

Björn Åkesson, MD

Department of Applied Nutrition and Food Chemistry, University of Lund, Sweden

Background: The purpose of this study was to evaluate the use of selenoprotein P as an indicator of selenium status in patients receiving home parenteral nutrition. Methods: Adult patients (n = 38) who had been on parenteral nutrition with no addition of selenium for 3 to 216 months were included in the study. Plasma samples were analyzed for selenium, selenoprotein P, and extracellular glutathione peroxidase (eGSHPx) using fluorimetry and newly developed radioimmunoassays. Results: The mean plasma (± SD) eGSHPx and selenoprotein P in the patients were 1.9 ± 1.2 mg/L and 0.7 ± 0.4 arbitrary units, respectively, which corresponds to about 50% of the concentration measured in the plasma of the reference subjects (4.0 ± 1.0 mg/L and 1.50 ± 0.17 arbitrary units). The mean plasma selenium concentration was 0.5 ± 0.4 µmol/L, which was approximately half of the concentration measured in the healthy subjects (1.1 ± 0.2 µmol/ L). Thirty-four (89%) and 20 (53%) patients, respectively, had selenoprotein P and eGSHPx values lower than mean - 2 SD of the reference material. The lowest values observed for selenoprotein P and eGSHPx were 3% and 2% of the reference mean. Selenoprotein P levels correlated significantly to eGSHPx (p = 0.88, p < .0001) and plasma selenium (p = 0.91, p < .0001). Conclusions: The positive correlations between selenoprotein P and eGSHPX and plasma selenium indicates that selenoprotein P may be used as a marker of selenium status in selenium-depleted patients. (Journal of Parenteral and Enteral Nutrition 20:287-291, 1996)

Journal of Parenteral and Enteral Nutrition, Vol. 20, No. 4, 287-291 (1996)
DOI: 10.1177/0148607196020004287


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