This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hensrud, D. D. Articles by Hall, L. G. Search for Related Content PubMed PubMed Citation Articles by Hensrud, D. D. Articles by Hall, L. G. Social Bookmarking                         What's this?

Stability of Heparin Anticoagulant Activity Over TIme in Parenteral Nutrition Solutions

Division of Preventive Medicine, Endocrinology/Metabolism and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Mary F. Burritt, PHD

Division of Clinical Biochemistry and Immunology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Larry G. Hall, MT, ASCP

Division of Clinical Biochemistry and Immunology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Background: Heparin added to parenteral nutrition solutions may decrease the incidence of central venous thrombosis in patients receiving home parenteral nutrition. However, there are little data regarding the stability of heparin over time under conditions similar to those associated with home parenteral nutrition: low concentrations of heparin stored in solutions containing amino acids and high concentrations of dextrose for more than 24 hours. Methods: The activity of porcine mucosal heparin was measured over time using an antifactor Xa assay in six IV solutions: four parenteral nutrition solutions containing 25% dextrose; 5% amino acids; trace elements; electrolytes ; and 3000, 5000, 10,000, or 20,000 units/L of heparin; one solution of 25% dextrose and 5000 units/L heparin; and one solution of 0.9% saline and 5000 units/L heparin. Results: In all solutions except 25% dextrose (without amino acids and additives), heparin activity remained stable within 4% of baseline up to 28 days. In the 25% dextrose solution, heparin activity declined by 3%, 6%, and 11% at 14, 21, and 28 days, respectively. Conclusion: Heparin activity was stable over time in the normal saline and parenteral nutrition solutions and decreased slightly from 2 to 4 weeks in the dextrose-containing solution. Based on these data, when is administered home parenteral nutrition containing components similar to the solutions used in this study, heparin may be added at the time of preparation of the home parenteral nutrition solution rather than just before administration, with no resultant loss of heparin activity over time. (Journal of Parenteral and Enteral Nutrition 20:219-221, 1996)

Journal of Parenteral and Enteral Nutrition, Vol. 20, No. 3, 219-221 (1996)
DOI: 10.1177/0148607196020003219


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?