This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Jin, M. B. Articles by Yamaoka, Y. Search for Related Content PubMed PubMed Citation Articles by Jin, M. B. Articles by Yamaoka, Y. Social Bookmarking                         What's this?

Significance of Nucleosides and a Nucleotide Mixture Infusion on Hepatic Energy Metabolism of 70% Hepatectomized Rabbits in Postoperative Phase

Second Department of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan, Department of Surgery , Kyoto Prefectural University of Medicine, Kyoto, Japan, Department of Surgery II, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokaji, Kamig yo-ku, Kyoto 602, Japan

Tetsuya Yamaguchi, MD

Second Department of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan

Yasuyuki Shimahara, MD

Second Department of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan, First Department of Surgery, School of Medicine, Ehime University, Ehime, Japan, Shiga University of Medical Science, Shiga, Japan

Masato Ichimiya, MD

Second Department of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan

Kolichi Kinoshita, MD

Second Department of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan

Takahiro Oka, MD

Department of Surgery , Kyoto Prefectural University of Medicine, Kyoto, Japan

Kazue Ozawa, MD

Second Department of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan, Shiga University of Medical Science, Shiga, Japan, First Department of Surgery, School of Medicine, Ehime University, Osen-gun, Ehime 791-02, Japan. **Present address: Shiga University of Medical Science, Otsu-shi, Shiga 520-21, Japan

Yoshio Yamaoka, MD

Second Department of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan

Background: The influence of administration of a nucleoside-nucleotide mixture on hepatic energy metabolism was investigated in 70% hepatectomized rabbits from 48 to 72 hours after hepatectomy. Methods: From 48 to 72 hours after hepatectomy, animals underwent continuous IV infusion of 2 mL/kg body weight/h of 9 g/LNaCl (group S), 5.99 mmol/Lnucleoside-nucleotide mixture (group N1) or 11.98 mmol/L nucleoside-nucleotide mixture (group N2). Results: At 72 hours, there was no significant difference in the hepatic adenylate energy charge among groups (S, 0.84 ± 0.01; N1, 0.82 ± 0.02; N2, 0.85 ± 0.01). The hepatic mitochondrial phosphorylation rate was 66.9 ± 2.5, 76.3 ± 11.1, and 108.4 ± 14.1 nmol ATP/mg mitochondrial protein/ min in groups S, N1, and N2, respectively. The value of group N2 was significantly higher than the value of group S (p < .01). In addition, DNA concentration of the remnant liver was 2.27 ± 0.07, 2.56 ± 0.17, and 3.19 ± 0.42 mg/g wet liver in groups S, N1, and N2, respectively, showing a significant increase in group N2 compared with group S (p < .05). Conclusion: A continuous IV infusion of a nucleoside-nucleotide mixture to 70% hepatectomized rabbits from 48 to 72 hours after hepatectomy prolonged an enhancement of the hepatic mitochondrial phosphorylation rate and elevated DNA content of the remnant liver. (journal of Parenteral and Enteral Nutrition 20:211-214, 1996)

Journal of Parenteral and Enteral Nutrition, Vol. 20, No. 3, 211-214 (1996)
DOI: 10.1177/0148607196020003211


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?