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Dietary Long-Chain Polyunsaturated Fatty Acids Influence the Recovery of Thioacetamide-Induced Liver Cirrhosis in Rats

Departamento de Bioquimica y Biologia Molecular, Universidad de Granada, Spain

Luis Fontana, PHD

Departamento de Bioquimica y Biologia Molecular, Universidad de Granada, Spain

María Isabel Torres, PHD

Departamento de Biologia Celular, Universidad de Granada, Spain

Isabel Fernández, BSc

Departamento de Biologia Celular, Universidad de Granada, Spain

Antonio Ríos, PHD

Departamento de Biologia Celular, Universidad de Granada, Spain

Fermín Sánchez de Medina, PHD

Departamento de Bioquimica y Biologia Molecular, Universidad de Granada, Spain

Ángel Gil, PHD

Departamento de Bioquimica y Biologia Molecular

Background: The aim of this study was to evaluate the dietary supplementation with -3 and -6 long-chain polyunsaturated fatty acids on the fatty acid composition of plasma and red blood cell membranes in rats with thioacetamide-induced liver cirrhosis. Methods: Thirty-eight female Wistar rats were given 300 mg thioacetamide/L in drinking water for 4 months to induce the experimental liver cirrhosis. Sixteen rats were used as controls. After treatment with thioacetamide, nine rats of each group were killed. Then, thioacetamide-treated rats were divided into three new groups, each receiving a different diet for 2 weeks: a semipurified diet (n = 9), the same diet supplemented with -3 long-chain polyunsaturated fatty acids (n = 10), or the same semipurified diet supplemented with -3 and -6 long-chain polyunsaturated fatty acids simultaneously (n = 10). The remaining control rats were fed the semipurified diet. Liver histology and plasma and erythrocyte fatty acid composition were assessed. Results: An apparent improvement of the histological damage took place in the rats fed the -3+ -6 -supplemented diet. The diet supplemented with polyunsaturated fatty acids of the -3 series induced increases in the -3 long-chain polyunsaturated fatty acid levels in total plasma lipids, plasma lipid fractions and in erythrocyte phospholipids, and decreases in -6 long-chain polyunsaturated fatty acids in erythrocyte phospholipids during the recovery of rats with thioacetamide-induced liver cirrhosis. The administration of the diet supplemented with both -3 and -6 long-chain polyunsaturated fatty acids contributed to increase the levels of total plasma saturated, monounsaturated, and -6 long-chain polyunsaturated fatty acids from cirrhotic rats. Conclusion: We conclude that the simultaneous supply of long-chain fatty acids of the -3 and the -6 series can be beneficial to improve the fatty acid status of this experimental model of liver cirrhosis. (Journal of Parenteral and Enteral Nutrition 19:461-469, 1995)

Journal of Parenteral and Enteral Nutrition, Vol. 19, No. 6, 461-469 (1995)
DOI: 10.1177/0148607195019006461


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