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The Effect of Selenium Supplementation on Skeletal and Cardiac Muscle in Selenium-Depleted Patients

Department of Gastroenterology, Rigshospitalet

Karin Ladefoged, MD

Department of Gastroenterology, Rigshospitalet

Ellinor Hylander, MD

Department of Gastroenterology, Rigshospitalet

Jette Christiansen

Department of Gastroenterology, Rigshospitalet

Henning Laursen, MD

Institute of Neuropathology, University of Copenhagen

Jens Halkjær Kristensen, MD

Laboratory of Clinical Physiology of Exercise, Rigshospitalet

Michael Linstow, MD

Laboratory of Clinical Physiology of Exercise, Rigshospitalet

Nina Beyer

Laboratory of Clinical Physiology of Exercise, Rigshospitalet

Rocco Liguori, MD

Department of Clinical Neurophysiology, Rigshospitalet

Harriet Dige-Petersen, MD

Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Copenhagen, Denmark

Birte Hjort Jensen

Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Copenhagen, Denmark

Stig Jarnum, MD

Department of Gastroenterology, Rigshospitalet

Background: The purpose of the present study was to evaluate the effect of sodium selenite on skeletal and cardiac muscular function in patients with severe Se deficiency. Methods: Skeletal and cardiac muscular function was investigated in 10 selenium depleted patients on long-term home parenteral nutrition because of short bowel syndrome. The following examinations were applied: Skeletal muscle biopsy, muscular force test (Kin-Com dynamometer test), electromyography (EMG) and radionuclide ventriculography. The patients were blindly randomized to intravenous supplementation with selenium 200 µg 5 to 7 times per week or placebo for 4 months. Hereafter the examinations were repeated. The patients randomized to placebo received selenium in an open study for a further 4 months and hereafter their skeletal and cardiac function was reevaluated. Results: Plasma selenium increased to normal levels from median .21 µmol/l (range 0 - .69) to 1.25 µmol/l (range .9 - 2.27) following selenium repletion. The muscle biopsies showed only minor abnormalities. The only change after selenium supplementation was a small but statistically significant increase of the mean diameter of fiber type 1. The muscle strength of the quadriceps muscle was unchanged after selenium substitution. EMG did not reveal signs of myopathy. The cardiac function was normal and remained unchanged. Conclusion: Despite severe selenium depletion ten patients on long term home parenteral nutrition had normal cardiac function, and no clinically significant signs of skeletal myopathy. The only change after selenium supplementation was a small but statistically significant increase of the mean diameter of muscle fiber type 1. (Journal of Parenteral and Enteral Nutrition 19:351-355, 1995)

Journal of Parenteral and Enteral Nutrition, Vol. 19, No. 5, 351-355 (1995)
DOI: 10.1177/0148607195019005351


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				T. Rannem, M. Persson-Moschos, Wenhu Huang, M. Staun, and B. Akesson Selenoprotein P in Patients on Home Parenteral Nutrition JPEN J Parenter Enteral Nutr, July 1, 1996; 20(4): 287 - 291. [Abstract] [PDF]