This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Malecki, E. A. Articles by Greger, J.L. Search for Related Content PubMed PubMed Citation Articles by Malecki, E. A. Articles by Greger, J.L. Social Bookmarking                         What's this?

Tissue Manganese Concentrations and Antioxidant Enzyme Activities in Rats Given Total Parenteral Nutrition With and Without Supplemental Manganese

Department of Nutritional Sciences, University of Wisconsin-Madison

Hui-Chen Lo, BS

Department of Nutritional Sciences, University of Wisconsin-Madison

Huan Yang, MD, PhD

Department of Nutritional Sciences, University of Wisconsin-Madison, Department of Biochemistry, University of Texas Health Science Center at San Antonio

Cindy D. Davis, PhD

Department of Nutritional Sciences, University of Wisconsin-Madison, National Cancer Institute, National Institutes of Health, Bethesda, MD

Denise M. Ney, PhD

Department of Nutritional Sciences, University of Wisconsin-Madison

J.L. Greger, PhD

Department of Nutritional Sciences, University of Wisconsin-Madison

Background: Manganese is an essential but potentially toxic mineral. Parenteral administration of manganese via total parenteral nutrition (TPN) bypasses homeostatic mechanisms (intestinal absorption and presystemic hepatic elimination). Our objective in this study was to determine the effect of supplemental manganese in TPN solutions on manganese status in a rat model. Methods: Male Sprague-Dawley rats underwent jugular catheterization and were given 61.0 ± 0.4 g/d TPN solution providing 0.5 ± 0.2 nmol manganese/g (Mn-; n = 6) or 16 ± 3 nmol manganese/g (Mn+; n = 7) for 7 days. Reference rats (RF; n = 8) were fed a purified diet containing 1.3 mmol manganese/g. Results: Liver manganese decreased in both TPN groups, but tibia, spleen, and pancreas manganese concentrations were greater in Mn+ rats than in Mn- or RF rats. Although no treatment differences were seen in heart or liver manganese superoxide dismutase activity, heart copper-zinc superoxide dismutase activity was lower in the Mn+ rats than in Mn- or RF rats (p < .05). Glutathione peroxidase activity was depressed in livers of both Mn- and Mn+ rats relative to RF rats (p < .0001), which was not due to selenium deficiency. Conclusions: Supplemental parenteral manganese is taken up to a greater extent by peripheral tissues than the liver. In this first report of antioxidant enzyme activities in animals maintained with TPN, we found that TPN as well as supplemental manganese can influence antioxidant enzyme activities. We conclude that it is generally unnecessary and potentially toxic to supplement TPN solutions with manganese during short-term usage. (Journal of Parenteral and Enteral Nutrition 19:222-226, 1995)

Journal of Parenteral and Enteral Nutrition, Vol. 19, No. 3, 222-226 (1995)
DOI: 10.1177/0148607195019003222


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. Lespine, Y. Fernandez, B. Periquet, A. Galinier, J. Garcia, F. Anglade, J. Ghisolfi, and J.-P. Thouvenot Total Parenteral Nutrition Decreases Liver Oxidative Metabolism and Antioxidant Defenses in Healthy Rats: Comparative Effect of Dietary Olive and Soybean Oil JPEN J Parenter Enteral Nutr, March 1, 2001; 25(2): 52 - 59. [Abstract] [PDF]

				D. Boggio Bertinet, M. Tinivella, F. Alessandro Balzola, A. de Francesco, O. Davini, L. Rizzo, P. Massarenti, M. Antonietta Leonardi, and F. Balzola Brain Manganese Deposition and Blood Levels in Patients Undergoing Home Parenteral Nutrition JPEN J Parenter Enteral Nutr, July 1, 2000; 24(4): 223 - 227. [Abstract] [PDF]

				W. S. Helton Editorial: Monitoring and Replacing Minerals and Vitamins in Critical Illness Nutr Clin Pract, June 1, 2000; 15(3): 117 - 119. [PDF]

				K. N. Khan, J. M. Andress, and P. F. Smith Toxicity of Subacute Intravenous Manganese Chloride Administration in Beagle Dogs Toxicol Pathol, July 1, 1997; 25(4): 344 - 350. [Abstract] [PDF]

				G. Alves, J. Thiebot, A. Tracqui, T. Delangre, C. Guedon, and E. Lerebours Neurologic Disorders Due to Brain Manganese Deposition in a Jaundiced Patient Receiving Long-Term Parenteral Nutrition JPEN J Parenter Enteral Nutr, January 1, 1997; 21(1): 41 - 45. [Abstract] [PDF]

				J.L. Greger and D.M. Ney Response to Dr Shenkin et al JPEN J Parenter Enteral Nutr, July 1, 1996; 20(4): 312 - 312. [PDF]

				A. Shenkin, C.A. Wardle, N.B.R. Roberts, and M. Baines Manganese Supplementation During TPN JPEN J Parenter Enteral Nutr, July 1, 1996; 20(4): 311 - 312. [PDF]