This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Langkamp-Henken, B. Articles by Proctor, K. G. Search for Related Content PubMed PubMed Citation Articles by Langkamp-Henken, B. Articles by Proctor, K. G. Pubmed/NCBI databases Medline Plus Health Information Diets Social Bookmarking                         What's this?

Fasting-Induced Reduction of Intestinal Reperfusion Injury

Departments of Physiology and Surgery, University of Tennessee, Memphis

Kenneth A. Kudsk, MD

Departments of Physiology and Surgery, University of Tennessee, Memphis

Kenneth G. Proctor, PHD

Departments of Physiology and Surgery, University of Tennessee, Memphis

Background: Fasting is associated with significant structural, functional, and metabolic alterations in the intestinal mucosa. Before abdominal surgery, patients are usually fasted the night before surgery or for a longer period of time if chronic illness is present. The splanchnic organs may experience varying degrees of ischemia/reperfusion as blood vessels are occluded during the various manipulations. Methods: To study whether fasting alters intestinal reperfusion injury, rats were fasted for 0 to 2 days, and the mesenteric artery was occluded for 30 minutes and then reperfused for 1 hour. Mucosal atrophy was quantitated by measuring jejunal villus height and crypt depth, and mucosal injury was quantitated by measuring jejunal villus width to villus height and mucosal integrity. To determine whether any effect of fasting on reperfusion injury was due to the absence of luminal nutrients or to a systemic nutrient deficiency, rats were fed parenterally for 7 days before ischemia/reperfusion. Results: A 1-day fast produced significant mucosal atrophy. Reperfusion in the O-day and 1-day fasted animals produced mucosal injury and additional mucosal atrophy. After a 2-day fast, there was no mucosal injury or mucosal atrophy other than that produced by fasting alone. Parenteral feeding before ischemia/reperfusion did not prevent ischemia/reperfusion induced mucosal atrophy and injury. Conclusions: The protective effect of a 2-day fast before intestinal ischemia/reperfusion cannot be attributed to the physical and chemical absence of food within the intestinal lumen. (Journal of Parenteral and Enteral Nutrition 19:127-132, 1995)

Journal of Parenteral and Enteral Nutrition, Vol. 19, No. 2, 127-132 (1995)
DOI: 10.1177/0148607195019002127


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. A. Kudsk Jonathan E. Rhoads Lecture: Of Mice and Men... and a Few Hundred Rats JPEN J Parenter Enteral Nutr, July 1, 2008; 32(4): 460 - 473. [Full Text] [PDF]