This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kelberman, I. Articles by Levine, G. M. Search for Related Content PubMed PubMed Citation Articles by Kelberman, I. Articles by Levine, G. M. Social Bookmarking                         What's this?

Effect of Fiber and Its Fermentation on Colonic Adaptation After Cecal Resection in the Rat

Gastroenterology Section, Temple University School of Medicine, Philadelphia

Brian C. Cheetham, MD

Gastroenterology Section, Temple University School of Medicine, Philadelphia

Jerome Rosenthal, BA

Division of Gastroenterology and Nutrition, Albert Einstein Medical Center

Gary M. Levine, MD

Division of Gastroenterology and Nutrition, Albert Einstein Medical Center, Gastroenterology Section, Temple University School of Medicine, Philadelphia

Background: The role of fiber in postresection adaptation is poorly understood. We examined the significance of short-chain fatty acids produced by intracolonic fiber fermentation during colonic adaptation. Methods: Rats underwent one of three surgeries: control laparotomy, cecal resection, or cecal resection with placement of perfusion catheter. Rats of each surgical group were randomly assigned to receive treatment regimens of standard fiber diet (with or without fermentation-suppressing antibiotics), fiber-free diet, or diet plus intracolonic perfusion of short-chain fatty acids. Adaptation parameters of mucosal weight, mucosal DNA and protein content, water absorption, and butyrate absorption were measured. Results: Compared with controls, postresection rats that were fed fiber had 65% greater basal and 112% greater butyrate-stimulated water absorption as well as 140% greater butyrate absorption. Fiber-fed rats exhibited significantly greater colonic weight and colonic mucosal protein after cecal resection. These changes were absent in postresection rats fed a fiber-free diet. Inhibition of fermentation by neomycin and metronidazole added to a standard fiber diet also prevented postresection adaptation. All adaptive changes were restored when the cecal-resection rats that were fed the fiber diet with antibiotics received an intracolonic infusion of short-chain fatty acids. Adaptation did not occur when short-chain fatty acids were infused into colons of postresection rats that were fed a fiber-free diet. Conclusions: Cecal resection leads to significant functional and structural changes in the adapting residual colon. Fermentation of dietary fiber by colonic flora to short-chain fatty acids is necessary, but it alone is not sufficient to mediate adaptation. (Journal of Parenteral and Enteral Nutrition 19:100-106, 1995)

Journal of Parenteral and Enteral Nutrition, Vol. 19, No. 2, 100-106 (1995)
DOI: 10.1177/0148607195019002100


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				T. P. O'Connor, M. M. Lam, and J. Diamond Magnitude of functional adaptation after intestinal resection Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1265 - R1275. [Abstract] [Full Text] [PDF]