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Arginine-Enriched Solution Induces a Marked Increase in Muscle Glutamine Concentration and Enhances Muscle Protein Synthesis in Tumor-Bearing Rats

Section of Biochemistry, Biological Research Laboratory, Taiho Pharmaceutical Co Ltd

Katsuo Ohwada, BS

Section of Biochemistry, Biological Research Laboratory, Taiho Pharmaceutical Co Ltd

Mitsuhiro Nagao, BS

Section of Biochemistry, Biological Research Laboratory, Taiho Pharmaceutical Co Ltd

Kenji Kitazato, BS

Section of Biochemistry, Biological Research Laboratory, Taiho Pharmaceutical Co Ltd

Yasuo Kishino, MD

The Department of Nutrition, School of Medicine, University of Tokushima, Japan

Using a transplantable Yoshida sarcoma in a rat model of total parenteral nutrition (TPN), we measured the effectiveness of an arginine-enriched amino acid solution (AI-82) on muscle glutamine concentration and muscle protein synthesis compared with that of a conventional amino acid solution (Proteaminl2). After tumor-bearing rats had been given one of two isocaloric TPN regimens for 6 days, [¹⁵N]glycine (99 atom %) containing TPN solution was infused into animals at a constant rate of 8 mg of [¹⁵N]glycine per hour for 18 hours, after which the liver, skeletal muscle (gastrocnemius muscle), and tumor protein synthesis rates were measured. A significantly increased whole muscle protein synthesis rate was observed in the AI-82 group; there was no difference in the whole liver and tumor protein synthesis rates between the two groups. When each TPN solution was administered for 1 week, muscle concentrations of arginine, ornithine, glutamine, and glutamate were considerably higher in the AI-82 group than in the Proteamin12 group, and these differences were also accompanied by a decrease in the plasma branched-chain amino acid (BCAA) (leucine, isoleucine, and valine) levels in the AI-82 group. The high levels of muscle glutamine concentration in the AI-82 group were investigated in connection with the high use of exogenous branched-chain amino acids. (Journal of Parenteral and Enteral Nutrition 18:491-496, 1994)

Journal of Parenteral and Enteral Nutrition, Vol. 18, No. 6, 491-496 (1994)
DOI: 10.1177/0148607194018006491


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