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New Experimental Model of Acute Renal Failure and Sepsis in Rats

Divisions of Nephrology and Hypertension and Medical Genetics, Department of Medicine and Pediatrics, Harbor-UCLA Medical Center, Torrance, California and the Schools of Medicine and Public Health, University of California Los Angeles, Los Angeles, California, University of Saarland, University Hospital Homburg/Saar, Division of Nephrology, 66421 Homburg/Saar, Germany

Ehsan Shahmir, MD

Divisions of Nephrology and Hypertension and Medical Genetics, Department of Medicine and Pediatrics, Harbor-UCLA Medical Center, Torrance, California and the Schools of Medicine and Public Health, University of California Los Angeles, Los Angeles, California

Essam Maasarani, MD

Divisions of Nephrology and Hypertension and Medical Genetics, Department of Medicine and Pediatrics, Harbor-UCLA Medical Center, Torrance, California and the Schools of Medicine and Public Health, University of California Los Angeles, Los Angeles, California

Salman Akhtar, MD

Divisions of Nephrology and Hypertension and Medical Genetics, Department of Medicine and Pediatrics, Harbor-UCLA Medical Center, Torrance, California and the Schools of Medicine and Public Health, University of California Los Angeles, Los Angeles, California

Vasuki Thevanayagam

Divisions of Nephrology and Hypertension and Medical Genetics, Department of Medicine and Pediatrics, Harbor-UCLA Medical Center, Torrance, California and the Schools of Medicine and Public Health, University of California Los Angeles, Los Angeles, California

Jaydutt V. Vadgama, PHD

Divisions of Nephrology and Hypertension and Medical Genetics, Department of Medicine and Pediatrics, Harbor-UCLA Medical Center, Torrance, California and the Schools of Medicine and Public Health, University of California Los Angeles, Los Angeles, California, Charles R Drew University of Medicine, Hawkins Building MP 3071D, 1621 E. 120th Street, Los Angeles, CA 90059

Joel D. Kopple, MD

Divisions of Nephrology and Hypertension and Medical Genetics, Department of Medicine and Pediatrics, Harbor-UCLA Medical Center, Torrance, California and the Schools of Medicine and Public Health, University of California Los Angeles, Los Angeles, California

Background: A rat model of acute renal failure (ARF) with sepsis (ARF+S) was developed to simulate the clinical syndrome of hypercatabolic illness in patients with ARF. Methods: Sepsis was created by ligation and needle puncture of the cecum; ARF was created by left renal artery clamping and contralateral nephrectomy. Results: Two studies were performed. In study 1, rats with sham surgery, sepsis, ARF, and ARF+S were examined for 48 hours. During the first 24 hours after surgery, ARF and ARF+S rats displayed increased urea and ammonia nitrogen appearances and abnormal plasma amino acid levels. These abnormalities were exaggerated in ARF+S rats. In study 2, sham, ARF, and ARF+S rats were injected with sodium bicarbonate or normal saline. During the first 24 hours after surgery, the ARF and ARF+S rats showed an increase in urea nitrogen appearance to 210% and 293%, respectively, of sham values, which was greater than the levels that have been previously reported. Sodium bicarbonate treatment did not influence nitrogen output. Conclusions: Rats with ARF+S may be a useful model for studying catabolic patients with ARF. The lack of effect of sodium bicarbonate on nitrogen balance merits additional study. (Journal of Parenteral and Enteral Nutrition 18:477-485, 1994)

Journal of Parenteral and Enteral Nutrition, Vol. 18, No. 6, 477-485 (1994)
DOI: 10.1177/0148607194018006477


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