This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Houdijk, A. P.J. Articles by Wesdorp, R. I.C. Search for Related Content PubMed PubMed Citation Articles by Houdijk, A. P.J. Articles by Wesdorp, R. I.C. Social Bookmarking                         What's this?

Glutamine-Enriched Enteral Diet Increases Renal Arginine Production

Department of Surgeryy, Free University Hospital, Amsterdam

PAUL A M. Van Leeuwen, MD, PHD

Department of Surgeryy, Free University Hospital, Amsterdam

Tom Teerlink, PHD

Clinical Chemistry, Free University Hospital, Amsterdam

Eveline L. Flinkerbusch

Department of Surgeryy, Free University Hospital, Amsterdam

Maria A. Boermeester, MD

Department of Surgeryy, Free University Hospital, Amsterdam

Hans P. Sauerwein, MD, PHD

Department of Surgeryy, Free University Hospital, Amsterdam

Robert I.C. Wesdorp, MD, PHD

Department of Surgeryy, Free University Hospital, Amsterdam

Background: Arginine (Arg) is generated in the kidney by the conversion of circulating citrulline. The most important source for circulating citrulline is the metabolism of glutamine (Gln) by the gut. In this study, we investigated the influence of an enteral diet enriched with Gln on renal Arg synthesis in the rat. Methods: Rats were fed a 12.5% Gln-enriched diet or an isocaloric, isonitrogenous control diet for 14 days. Kidney plasma flow and arterial and renal venous plasma levels of a number of amino acids were measured, and kidney amino acid fluxes were calculated. Results: Compared with the control diet, Gln enrichment resulted in significantly higher arterial plasma levels of circulating citrulline (30%, p < .0001) and Arg (31%, p < .0005). The uptake of circulating citrulline and the subsequent production of Arg by the kidneys were significantly higher in the Gln-enriched group (40% and 38%, respectively) and showed an equimolar relationship in both the control (r = .84, p < .0001) and the Gln-enriched group (r = .83, p < .0001). Conclusions: The findings indicate that enteral Gln supplementation caused significantly increased arterial plasma levels of Arg as a result of increased renal Arg production from circulating citrulline. Considering the multiple important biologic properties of Arg, the reported beneficial effects of Gln in catabolic states might be explained in part by increased renal Arg production. (Jouynal of Parenteral and Enteral Nutrition 18:422-426, 1994)

Journal of Parenteral and Enteral Nutrition, Vol. 18, No. 5, 422-426 (1994)
DOI: 10.1177/0148607194018005422


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				G. C Ligthart-Melis, M. C. van de Poll, P. G Boelens, C. H. Dejong, N. E. Deutz, and P. A. van Leeuwen Glutamine is an important precursor for de novo synthesis of arginine in humans Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1282 - 1289. [Abstract] [Full Text] [PDF]

				M. C. G. van de Poll, G. C. Ligthart-Melis, P. G. Boelens, N. E. P. Deutz, P. A. M. van Leeuwen, and C. H. C. Dejong Intestinal and hepatic metabolism of glutamine and citrulline in humans J. Physiol., June 1, 2007; 581(2): 819 - 827. [Abstract] [Full Text] [PDF]

				T. Umenai, Y. Nakajima, D. I. Sessler, S. Taniguchi, H. Yaku, and T. Mizobe Perioperative Amino Acid Infusion Improves Recovery and Shortens the Duration of Hospitalization After Off-Pump Coronary Artery Bypass Grafting Anesth. Analg., December 1, 2006; 103(6): 1386 - 1393. [Abstract] [Full Text] [PDF]

				P. G. Boelens, G. C. Melis, P. A. van Leeuwen, G. A. ten Have, and N. E. Deutz Route of administration (enteral or parenteral) affects the contribution of L-glutamine to de novo L-arginine synthesis in mice: a stable-isotope study Am J Physiol Endocrinol Metab, October 1, 2006; 291(4): E683 - E690. [Abstract] [Full Text] [PDF]

				P. G. Boelens, P. A. M. van Leeuwen, C. H. C. Dejong, and N. E. P. Deutz Intestinal renal metabolism of L-citrulline and L-arginine following enteral or parenteral infusion of L-alanyl-L-[2,15N]glutamine or L-[2,15N]glutamine in mice Am J Physiol Gastrointest Liver Physiol, October 1, 2005; 289(4): G679 - G685. [Abstract] [Full Text] [PDF]

				M. C. van de Poll, P. B Soeters, N. E. Deutz, K. C. Fearon, and C. H. Dejong Renal metabolism of amino acids: its role in interorgan amino acid exchange Am. J. Clinical Nutrition, February 1, 2004; 79(2): 185 - 197. [Abstract] [Full Text] [PDF]

				P. G Boelens, A. P. Houdijk, H. J. Haarman, R. J Nijveldt, and P. A. van Leeuwen Glutamine-enriched enteral nutrition decreases infectious complications in trauma patients Am. J. Clinical Nutrition, July 1, 2002; 76(1): 253 - 254. [Full Text] [PDF]

				P. G. Boelens, R. J. Nijveldt, A. P. J. Houdijk, S. Meijer, and P. A. M. van Leeuwen Glutamine Alimentation in Catabolic State J. Nutr., September 1, 2001; 131(9): 2569S - 2577. [Abstract] [Full Text] [PDF]

				G. K. Savy Enteral Glutamine Supplementation: Clinical Review and Practical Guidelines Nutr Clin Pract, December 1, 1997; 12(6): 259 - 262. [Abstract] [PDF]