This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by De Gaetano, A. Articles by Greco, A. V. Search for Related Content PubMed PubMed Citation Articles by De Gaetano, A. Articles by Greco, A. V. Social Bookmarking                         What's this?

Kinetics of Medium-Chain Triglycerides and Free Fatty Acids in Healthy Volunteers and Surgically Stressed Patients

CNR, Centro Fisiopatologia Shock, and Clinica Chirurgica, Cattedra di Chirurgia Sostitutiva e Trapianti d'Organo, Catholic University, Rome

Marco Castagneto, MD, FACS

CNR, Centro Fisiopatologia Shock, and Clinica Chirurgica, Cattedra di Chirurgia Sostitutiva e Trapianti d'Organo, Catholic University, Rome

Geltrude Mingrone, MD

Clinica Medica, Gastroenterologia e Malattie Metaboliche, Catholic University, Rome

Giuliano Gangeri, MD

CNR, Centro Fisiopatologia Shock, and Clinica Chirurgica, Cattedra di Chirurgia Sostitutiva e Trapianti d'Organo, Catholic University, Rome

Gabriele Sganga, MD

CNR, Centro Fisiopatologia Shock, and Clinica Chirurgica, Cattedra di Chirurgia Sostitutiva e Trapianti d'Organo, Catholic University, Rome

Pietro A. Tataranni, MD

Clinica Medica, Gastroenterologia e Malattie Metaboliche, Catholic University, Rome

Comasia Raguso, MD

Clinica Medica, Gastroenterologia e Malattie Metaboliche, Catholic University, Rome

Aldo V. Greco, MD

Clinica Medica, Gastroenterologia e Malattie Metaboliche, Catholic University, Rome

To determine the hydrolysis rate of medium-chain triglycerides (MCTs) to medium-chain free fatty acids (MCFAs) and the disposition rate of MCFAs, five healthy volunteers (H) and eight surgically stressed patients (S) received 0.5 mL of Lipofundin 20% per kilogram body weight as an intravenous bolus. Serum MCTs (C8 and C10) and MCFAs were measured by high-performance liquid chromatography during the 120 minutes postinjection. A linear two-compartment model was found to be descriptive and robust: the apparent volumes of distribution were found to be similar in healthy and surgical subjects for both MCTs and MCFAs. The first-order transformation rate constant (hydrolysis) from MCTs to MCFAs was not significantly different between the H and S groups (overall 0.112 ± 0.022/min, C8; 0.078 ± 0.020/min, C10). The rate constant for tissue MCFA uptake from plasma was significantly different between S and H subjects both for C10 alone (H: 0.0337 ± 0.0078; S: 0.1194 ± 0.0240; p = .020) and for C8 and C10 together (H: 0.0382 ± 0.0054; S: 0.1012 ± 0.0168; p = .008), whereas it failed to attain significance when C8 alone was considered (H: 0.047 ± 0.0077; S: 0.0829 ± 0.0230; p = .210). These results show that use of MCTs is increased in surgical patients because of enhanced tissue uptake of the corresponding free fatty acids, whereas there does not seem to be an increase of MCT hydrolysis in response to acute disease. This would indicate that the stressed patient is in fact able to effectively use this alternative lipid substrate in the face of increased metabolic demand. (Journal of Parenteral and Enteral Nutrition 18:134-140, 1994)

Journal of Parenteral and Enteral Nutrition, Vol. 18, No. 2, 134-140 (1994)
DOI: 10.1177/0148607194018002134


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. Panunzi, A. De Gaetano, and G. Mingrone Approximate linear confidence and curvature of a kinetic model of dodecanedioic acid in humans Am J Physiol Endocrinol Metab, November 1, 2005; 289(5): E915 - E922. [Abstract] [Full Text] [PDF]

				A. de Gaetano, G. Mingrone, M. Castagneto, G. Benedetti, A. V. Greco, and G. Gasbarrini Kinetics of dodecanedioic acid triglyceride in rats Am J Physiol Endocrinol Metab, March 1, 1999; 276(3): E497 - E502. [Abstract] [Full Text] [PDF]