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Effects of Amino Acids in Mixtures Given by Enteral or Parenteral Route on Intestinal Morphology and Hydrolases in Rats

Unité de Biologie Cellulaire et Physiopathologie Digestive, INSERM, Strasbourg, France

Michel Galluser, MS

Unité de Biologie Cellulaire et Physiopathologie Digestive, INSERM, Strasbourg, France

Michel Hasselmann, MD

Unité de Biologie Cellulaire et Physiopathologie Digestive, INSERM, Strasbourg, France

Michel Doffoel, MD

Unité de Biologie Cellulaire et Physiopathologie Digestive, INSERM, Strasbourg, France

Francis Raul, PHD

Unité de Biologie Cellulaire et Physiopathologie Digestive, INSERM, Strasbourg, France

This study compares the effects of amino acid addition to an elemental liquid diet containing carbohydrates and triglycerides given either intragastrically or intravenously on the morphology and on hydrolase activities in the jejunum and ileum of adult rats. The isocaloric mixtures were administered for 4 days and control rats received an isocaloric laboratory diet orally. Independent of their content in amino acid, all mixtures given intravenously caused a drop in mucosal weight and a shortening of the height of the villi in both the jejunum and ileum. By enteral route, the addition of amino acids to a carbohydrate-triglyceride liquid diet led to the maintenance of normal villus height (this effect being prominent in the ileum) and to a significant increase of jejunal sucrase and aminopeptidase activities when compared with the carbohydrate-triglyceride mixture. Feeding the mixtures by parenteral route caused a significant drop of both enzyme activities. In contrast, lactase activity was generally not modified by the route of nutrient administration or by the composition of the diets. However, the absence of amino acid in the mixture given intravenously caused a specific drop of lactase activity in the ileum. Ileal sucrase activity was lowered dramatically by intragastric or intravenous feeding of the elemental diets. This effect was not modulated by the presence of amino acids. The presence of amino acids caused a significant drop of aminopeptidase activity in the ileum independently of the route of administration when compared with animals receiving the carbohydrate-triglyceride liquid diet. The present report shows that amino acids present in the liquid diet given by either enteral or parenteral route are able to modulate the morphology and hydrolytic functions along the small intestine. Because amino acids are preferentially absorbed by the jejunum, the effects observed at the level of the ileum might be related to hormonal and/or biliopancreatic regulations. (Journal of Parenteral and Enteral Nutrition 16: 259-263, 1992)

Journal of Parenteral and Enteral Nutrition, Vol. 16, No. 3, 259-263 (1992)
DOI: 10.1177/0148607192016003259


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