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Effects of Pectin and Cellulose on Fat Absorption After Massive Small-Bowel Resection in Weanling Rats

Department of Pediatric Surgery, Kagawa Medical School, Miki, Kitagun, Kagawa, Japan

Takuji Todani, MD

Department of Pediatric Surgery, Kagawa Medical School, Miki, Kitagun, Kagawa, Japan

Yasuhiro Watanabe, MD

Department of Pediatric Surgery, Kagawa Medical School, Miki, Kitagun, Kagawa, Japan

Sadashige Uemura, MD

Department of Pediatric Surgery, Kagawa Medical School, Miki, Kitagun, Kagawa, Japan

Yasuhisa Sato, MD

Department of Pediatric Surgery, Kagawa Medical School, Miki, Kitagun, Kagawa, Japan

Yoshiki Morotomi, MD

Department of Pediatric Surgery, Kagawa Medical School, Miki, Kitagun, Kagawa, Japan

The effects of pectin and cellulose on fat absorption after massive small-bowel resection were studied in rats. Weanling Wistar rats underwent 80% resection of the small intestine with gastrostomy, and fat emulsion labeled with ¹⁴C-linoleate was given via a gastrostomy tube for the fat absorption test on the 10th postoperative day. They were classified into three groups by diet as follows: E group, a fiber-free, chemically defined diet (CDD); EP group, CDD with 2% pectin; and EC group, CDD with 2% cellulose. The cumulative and hourly output of ¹⁴C in the expired air, the absorption rate of ¹⁴C in the intestine, and the metabolic utilization rate of ¹⁴C were calculated. The cumulative ¹⁴CO₂ output was significantly lower in the EC group than in the E and EP groups. However, there was no significant difference in the ¹⁴CO₂ output between the E and EP groups. The highest hourly ¹⁴CO₂ output in the E and EP groups was observed during the first 2 hours. However, in the EC group, this fluctuated at low levels. No significant difference in the 1-¹⁴C-linoleate absorption rate was observed between the E and EP groups, whereas it was significantly lower in the EC group than in the E and EP groups. The metabolic utilization rate of 1-¹⁴C-linoleate showed no significant difference among the three groups. These data suggest that an addition of pectin to CDD does not impair small intestinal absorption of 1-¹⁴C-linoleate after massive small-bowel resection, and an addition of cellulose decreases absorption of 1-¹⁴C-linoleate. (Journal of Parenteral and Enteral Nutrition 16: 255-258, 1992)

Journal of Parenteral and Enteral Nutrition, Vol. 16, No. 3, 255-258 (1992)
DOI: 10.1177/0148607192016003255


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