This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Mori, E. Articles by Kobayashi, K. Search for Related Content PubMed PubMed Citation Articles by Mori, E. Articles by Kobayashi, K. Social Bookmarking                         What's this?

Metabolic Effect of Short-Term Total Parenteral Nutrition Highly Enriched With Leucine or Valine in Rats Recovering From Severe Trauma

Trauma and Critical Care Center, Teikyo University School of Medicine, Itabashi, Tokyo, Japan

Masaharu Hasebe, MD

Trauma and Critical Care Center, Teikyo University School of Medicine, Itabashi, Tokyo, Japan

Kunio Kobayashi, MD

Trauma and Critical Care Center, Teikyo University School of Medicine, Itabashi, Tokyo, Japan

The metabolic impact of infusing a large amount of leucine (Leu) or valine (Val) was examined with regard to the corrective effect of total parenteral nutrition (TPN). Rats recovering from severe sepsis received either Leu- or Valenriched TPN solution for 30 hours. The in vivo behavior of the amino acids administered was explored by a pulse injection of ¹⁴ C-labeled Leu or Val. The recovery of ¹⁴CO₂ from Leu increased by 64% in the septic rats of Leu-TPN group (41% of dose; p < .01), as compared with control rats receiving the same TPN solution, whereas no significant rise in the ¹⁴CO₂ recovery from Val occurred in the septic rats given Val-TPN (45% of dose) in comparison with the corresponding controls. The enhancement of Leu catabolism to CO ₂ in the Leu-TPN group was compatible with the alterations of urinary nitrogen excretion, plasma Leu level, and metabolite contents of liver and muscle. The only difference in metabolite levels observed between the two TPN groups was in hepatic total adenine nucleotides. Plasma amino acid levels were largely unaffected by infusion of these TPN solutions highly enriched with branched-chain amino acids (45%), except for an approximately threefold elevation of the Val level in Val-TPN rats. Thus, when administered in a large quantity during such short-term TPN, Leu can exert its metabolic effect without causing an imbalance in plasma amino acids under severe catabolic conditions. (Journal of Parenteral and Enteral Nutrition 16: 236-240, 1992)

Journal of Parenteral and Enteral Nutrition, Vol. 16, No. 3, 236-240 (1992)
DOI: 10.1177/0148607192016003236


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J.-P. De Bandt and L. Cynober Therapeutic Use of Branched-Chain Amino Acids in Burn, Trauma, and Sepsis J. Nutr., January 1, 2006; 136(1): 308S - 313S. [Abstract] [Full Text] [PDF]

				M. Hasebe, H. Suzuki, E. Mori, J. Furukawa, K. Kobayashi, and Y. Ueda Glutamate in Enteral Nutrition: Can Glutamate Replace Glutamine in Supplementation to Enteral Nutrition in Burned Rats? JPEN J Parenter Enteral Nutr, September 1, 1999; 23(5_suppl): S78 - S82. [Abstract] [PDF]