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Clinical and Immunologic Effects of Lipid-Based Parenteral Nutrition in AIDS

Division of Critical Care Medicine, Department of Anesthesiology, Montefiore Medical Center and the Albert Einstein College of Medicine

Arye Rubinstein

Departments of Pediatrics, Microbiology, and Immunology, Albert Einstein College of Medicine, Bronx, New York

Jeffrey Askanazi

Division of Critical Care Medicine, Department of Anesthesiology, Montefiore Medical Center and the Albert Einstein College of Medicine

Terry Calvelli

Departments of Pediatrics, Microbiology, and Immunology, Albert Einstein College of Medicine, Bronx, New York

Tadd Lazarus

St Clares Hospital, New York

Olli Kirvelä

Division of Critical Care Medicine, Department of Anesthesiology, Montefiore Medical Center and the Albert Einstein College of Medicine

David P. Katz

Division of Critical Care Medicine, Department of Anesthesiology, Montefiore Medical Center and the Albert Einstein College of Medicine

The effect of lipid-based parenteral nutrition was assessed in eight patients with AIDS and weight loss of 10% or greater. All patients received home parenteral nutrition consisting of a lipid-based system with 50% of nonprotein calories given as fat. Measurements were made of body weight, serum albumin, and immune function as assessed by mitogen responses, P24 antigen levels and T-cell counts. Over a period of 2 months, weight gain and improved well-being were noted in all patients. An improved in vitro lymphocyte mitogenic response to phytohemagglutinin and to concanavalin A was also noted. No change in T-cell subsets was observed. Viral cultures and P24 serum levels also remained unchanged. Lipid-based parenteral nutrition is safe and probably efficacious in AIDS. (Journal of Parenteral and Enteral Nutrition 16:165-167, 1992)

Journal of Parenteral and Enteral Nutrition, Vol. 16, No. 2, 165-167 (1992)
DOI: 10.1177/0148607192016002165


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