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Optimal Ratio of Individual Branched-Chain Amino Acids in Total Parenteral Nutrition of Injured Rats

Department of Biochemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., Osaka, Japan

Tetsuya Kishi, PHD

Department of Biochemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., Osaka, Japan

Motoyo Morita, BS

Department of Biochemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., Osaka, Japan

Keiko Ikeda, BS

Department of Biochemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., Osaka, Japan

Hideaki Shima, MS

Department of Biochemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., Osaka, Japan

Tadashi Sato, PHD

Department of Biochemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., Osaka, Japan

In this study, we investigated the optimal ratio of individual branched-chain amino acids (BCAA) in a balanced amino acid infusion in laparotomized rats. The total BCAA contents of four amino acid infusions were fixed at 31% of total amino acids. The weight ratios of individual BCAA (isoleucine:leucine:valine) in the solutions were 1:0.5:1, 1:1:1, 1:2:1, and 1:4:1, respectively. The laparotomized rats were infused with about 140 mg (experiment 1) and 100 mg (experiment 2) of nitrogen and 10 g of glucose daily for 7 days. In both experiments, no marked difference was observed in the mean cumulative 7-day nitrogen balance and the urinary 3-methylhistidine levels of all the groups. The BCAA concentrations and the molar ratios of individual BCAA in plasma were disarranged by the infusion of the 1:0.5:1 and 1:4:1 solutions. The infusion of the 1:1:1 and 1:2:1 solutions tended, however, to allow the values to approach the preinfusion values. These results suggest that the optimal ratio of individual BCAA in an amino acid infusion lies between 1:1:1 and 1:2:1 for this injured rat model in total parenteral nutrition. (Journal of Parenteral and Enteral Nutrition 15:612-618, 1991)

Journal of Parenteral and Enteral Nutrition, Vol. 15, No. 6, 612-618 (1991)
DOI: 10.1177/0148607191015006612


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