This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Tashiro, T. Articles by Okui, K. Search for Related Content PubMed PubMed Citation Articles by Tashiro, T. Articles by Okui, K. Social Bookmarking                         What's this?

Increased Lipoprotein X Causes Hyperlipidemia During Intravenous Administration of 10% Fat Emulsion in Man

First Department of Surgery, Chiba Uniuersity School of Medicine, Chiba, Japan

Yoshiya Mashima, M.D.

First Department of Surgery, Chiba Uniuersity School of Medicine, Chiba, Japan

Hideo Yamamori, M.D.

First Department of Surgery, Chiba Uniuersity School of Medicine, Chiba, Japan

Kazuo Horibe, M.D.

First Department of Surgery, Chiba Uniuersity School of Medicine, Chiba, Japan

Masahiko Nishizawa, M.D.

First Department of Surgery, Chiba Uniuersity School of Medicine, Chiba, Japan

Masao Sanada, M.D.

First Department of Surgery, Chiba Uniuersity School of Medicine, Chiba, Japan

Katsuji Okui, M.D.

First Department of Surgery, Chiba Uniuersity School of Medicine, Chiba, Japan

To clarify the mechanisms of hyperlipidemia during intravenous Intralipid 10%, lipoprotein profiles including lipoprotein X were studied in 13 patients receiving 2.0 g of fat per kilogram per day by Intralipid 10% over a period of 8 weeks. All patients were fed exclusively by total parenteral nutrition providing 1.1 g of amino acid and 30 kcal/kg per day. Intravenous administration of Intralipid 10% caused a marked increase of low-density lipoprotein (LDL), phospholipid, and cholesterol, especially free cholesterol, whereas triglyceride, very-low-density lipoprotein, and high-density lipoprotein remained within the normal range. Lipid composition of LDL approximated that of lipoprotein X progressively with the intravenous Intralipid 10%. Quantification of lipoprotein X revealed that its increase was proportionate with that of LDL and total lipid. From these findings, hyperlipidemia during intravenous Intralipid 10% is induced almost exclusively by the increased lipoprotein X. (Journal of Parenteral and Enteral Nutrition 15:546-550, 1991)

Journal of Parenteral and Enteral Nutrition, Vol. 15, No. 5, 546-550 (1991)
DOI: 10.1177/0148607191015005546


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. Ling Yeh, J. Chen Tasi, and W. Jao Chen Effects of Soybean Oil and Fish Oil Emulsions on Glucose and Lipid Metabolism in Streptozotocin-Induced Diabetic Rats Receiving Total Parenteral Nutrition JPEN J Parenter Enteral Nutr, September 1, 1998; 22(5): 297 - 301. [Abstract] [PDF]

				M. Ekelund, B. Roth, H. Trelde, U. Ekstrom, and P. Nilsson-Ehle Effects of Total Parenteral Nutrition on Lipid Metabolism in Rats JPEN J Parenter Enteral Nutr, November 1, 1994; 18(6): 503 - 509. [Abstract] [PDF]