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Continuous Infusion of Insulin in Hyperglycemic Low-Birth Weight Infants Receiving Parenteral Nutrition with and without Lipid Emulsion

Department of Pediatrics, University of South Florida, Department of Pharmacotherapy and Research, Tampa General Hospital, Tampa, Florida

Maria L. Santeiro, PHARM. D.

Department of Pediatrics, University of South Florida, Department of Pharmacotherapy and Research, Tampa General Hospital, Tampa, Florida

John I. Malone, M.D.

Department of Pediatrics, University of South Florida, Department of Pharmacotherapy and Research, Tampa General Hospital, Tampa, Florida

The efficiency of a continuous infusion of insulin in improving glucose tolerance was compared in two groups of very low-birth weight infants (mean ± SEM birth weights 757 ± 40 vs 828 ± 80 g and gestational ages 27.6 ± 0.7 vs. 27.2 ± 0.5 weeks) receiving total parenteral nutrition with and without the addition of lipid emulsion to the nutrition regimen. The mean ± SEM cumulative doses of insulin (0.87 ± 0.1 vs 1.15 ± 0.3 U/kg) and hours required to decrease the blood glucose level to 120 mg/dL (9.1 ± 0.8 vs 9.5 ± 1.0 hours) were similar. Insulin was delivered with a syringe pump used for other routine purposes in the neonatal intensive care unit. Continuous intravenous insulin infusion is an effective, inexpensive, safe method for maintaining glucose homeostasis in low-birth weight infants who develop hyperglycemia as a consequence of total parenteral nutrition. (Journal of Parenteral and Enteral Nutrition 15:417-420, 1991)

Journal of Parenteral and Enteral Nutrition, Vol. 15, No. 4, 417-420 (1991)
DOI: 10.1177/0148607191015004417


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