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Factors Which Regulate Net Hepatic Glucose Uptake In Vivo

Department of Molecular Physiology and Biophysics, Vanderbilt Uniuersity Medical Center, Nashuille, Tennessee

Michael J. Pagliassotti

Department of Molecular Physiology and Biophysics, Vanderbilt Uniuersity Medical Center, Nashuille, Tennessee

Sharon R. Myers

Department of Molecular Physiology and Biophysics, Vanderbilt Uniuersity Medical Center, Nashuille, Tennessee

Bess Adkins-Marshall

Department of Molecular Physiology and Biophysics, Vanderbilt Uniuersity Medical Center, Nashuille, Tennessee

Owen P. Mcguinness

Department of Molecular Physiology and Biophysics, Vanderbilt Uniuersity Medical Center, Nashuille, Tennessee

The regulation of net hepatic glucose uptake in vivo occurs by way of the hormonal milieu (insulin and glucagon), the glucose level, and the route of glucose delivery. Hyperglycemia in the absence of changes in pancreatic hormones (i.e., increased insulin and/or decreased glucagon) does not elicit significant glucose uptake by the liver. Net hepatic glucose uptake is augmented in a dose-dependent manner by a rise in insulin and is further stimulated by the presence of a "portal signal." The presence of coordinated changes in insulin, glucagon, and the glucose level in combination with the "portal signal" ensures adequate glucose uptake by the liver in response to a meal. (Journal of Parenteral and Enteral Nutrition 15:71S-73S,1991)

Journal of Parenteral and Enteral Nutrition, Vol. 15, No. 3, 71S-73S (1991)
DOI: 10.1177/014860719101500371S


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