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Effect of Taurine on Total Parenteral Nutrition-Associated Cholestasis

Departments of Pediatrics, Nutrition and Pharmacology, University of Montreal and Centre de Recherche Pediatrique, Hôpital Ste-Justine, Montreal, Department of Pediatrics, University of Sherbrooke, Sherbrooke, Quebec, H3T 1C5, Canada

Claude C. Roy

Departments of Pediatrics, Nutrition and Pharmacology, University of Montreal and Centre de Recherche Pediatrique, Hôpital Ste-Justine, Montreal, Department of Pediatrics, University of Sherbrooke, Sherbrooke, Quebec, H3T 1C5, Canada

Guy Lepage

Departments of Pediatrics, Nutrition and Pharmacology, University of Montreal and Centre de Recherche Pediatrique, Hôpital Ste-Justine, Montreal, Department of Pediatrics, University of Sherbrooke, Sherbrooke, Quebec, H3T 1C5, Canada

Aline Perea

Departments of Pediatrics, Nutrition and Pharmacology, University of Montreal and Centre de Recherche Pediatrique, Hôpital Ste-Justine, Montreal, Department of Pediatrics, University of Sherbrooke, Sherbrooke, Quebec, H3T 1C5, Canada

Robert Giguère

Departments of Pediatrics, Nutrition and Pharmacology, University of Montreal and Centre de Recherche Pediatrique, Hôpital Ste-Justine, Montreal, Department of Pediatrics, University of Sherbrooke, Sherbrooke, Quebec, H3T 1C5, Canada

Ibrahim Yousef

Departments of Pediatrics, Nutrition and Pharmacology, University of Montreal and Centre de Recherche Pediatrique, Hôpital Ste-Justine, Montreal, Department of Pediatrics, University of Sherbrooke, Sherbrooke, Quebec, H3T 1C5, Canada

Beatriz Tuchweber

Departments of Pediatrics, Nutrition and Pharmacology, University of Montreal and Centre de Recherche Pediatrique, Hôpital Ste-Justine, Montreal, Department of Pediatrics, University of Sherbrooke, Sherbrooke, Quebec, H3T 1C5, Canada

A decrease in the formation/secretion of bile has been well documented in animals on total parenteral nutrition (TPN). Either an excess or an imbalance of amino acids (AA) has been most often implicated. In view of recent work showing that taurine promotes bile flow, bile acid secretion, and protects against hepatotoxic bile acids, the effect of adding taurine (15 mg/dL) to an AA solution was examined in guinea pigs on TPN for 3 days. The TPN-taurine group had a larger bile flow than the group without taurine and had bile acid secretory rates (BASR) similar to those of controls who were on saline by central catheter and had free access to food. Bile composition showed an increase in the secondary bile acid, 7-ketolithocholate and a concomitant decrease in chenodeoxycholate (CDC) in both experimental groups. Taurine led to a reversal of the usual predominance of glycine over taurine conjugated bile acids as well as to increases in HC03 in cholesterol secretion. In response to a challenge with a large load of CDC, the TPN-taurine animals increased their BASR beyond those observed in the two other groups. These observations suggest that the addition of taurine to TPN solutions could play a role in the prevention of altered biliary function associated with AA solutions. (Journal of Parenteral and Enteral Nutrition 15:247-251, 1991)

Journal of Parenteral and Enteral Nutrition, Vol. 15, No. 3, 247-251 (1991)
DOI: 10.1177/0148607191015003247


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