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Hormonal and Metabolic Response to Operative Stress in the Neonate

Section of Pediatric Surgery, Mott Children's Hospital and University of Michigan Medical School, Ann Arbor, Michigan

Arnold G. Coran, M.D.

Section of Pediatric Surgery, Mott Children's Hospital and University of Michigan Medical School, Ann Arbor, Michigan

It is evident from this review that newborns, even those born prematurely, are capable of mounting an endocrine and metabolic response to operative stress. Unfortunately, many of the areas for which a relatively well-characterized response exists in adults are poorly documented in neonates. As is the case in adults, the response seems to be primarily catabolic in nature because the combined hormonal changes include an increased release of catabolic hormones such as catecholamines, glucagon, and corticosteroids coupled with a suppression of and peripheral resistance to the effects of the primary anabolic hormone, insulin. (Journal of Parenteral and Enteral Nutrition 15:215-238, 1991)

Journal of Parenteral and Enteral Nutrition, Vol. 15, No. 2, 215-238 (1991)
DOI: 10.1177/0148607191015002215


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