This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Lidor, C. Articles by Gazit, D. Search for Related Content PubMed PubMed Citation Articles by Lidor, C. Articles by Gazit, D. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB ALUMINUM CALCIUM COMPOUNDS CALCIUM, ELEMENTAL DESFERRIOXAMINE Social Bookmarking                         What's this?

Successful High-Dose Calcium Treatment of Aluminum-Induced Metabolic Bone Disease in Long-Term Home Parenteral Nutrition

Department of Orthopedic Surgery, Sapir Medical Center, Kfar Saba, and Sackler School of Medicine, Tel Aviv University

Ivan Schwartz, M.D.

Department of Surgery "A.", Sapir Medical Center, Kfar Saba, and Sackler School of Medicine, Tel Aviv University

Uri Freund, M.D.

Department of Surgery "A.", Sapir Medical Center, Kfar Saba, and Sackler School of Medicine, Tel Aviv University

Dan Gazit, D.M.D.

Bone Laboratory, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem, Israel

A patient who developed severe metabolic bone disease is presented. He had received long-term home parenteral nutrition (HPN) following extensive small bowel resection after mesenteric vein thrombosis. Bone disease caused by aluminum intoxication had components of osteomalacia and low-turnover osteoporosis. Aluminum was detected at the surface of mineralized bone and was elevated in the serum, resulting in a positive deferoxamine infusion test.

One year of treatment with high doses of calcium (up to 24 mEq per day) significantly diminished the patient's bone pain, increased the serum levels of calcium, abolished aluminum deposits in the mineralized trabecula, improved bone formation, and increased trabecular bone volume as assessed by repeated histomorphometric analysis. (Journal of Parenteral and Enteral Nutrition 15:202-206, 1991)

Journal of Parenteral and Enteral Nutrition, Vol. 15, No. 2, 202-206 (1991)
DOI: 10.1177/0148607191015002202


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				T. G. Baumgartner Enteral and Parenteral Electrolyte Therapeutics Nutr Clin Pract, August 1, 2001; 16(4): 226 - 232. [PDF]

				W. W.K. Koo Review: Parenteral Nutrition-Related Bone Disease JPEN J Parenter Enteral Nutr, July 1, 1992; 16(4): 386 - 394. [Abstract] [PDF]

				W. W.K. Koo Nutrition-Related Bone Disease JPEN J Parenter Enteral Nutr, July 1, 1992; 16(4): 400 - 400. [PDF]

				W. W.K. Koo and R. W. Chesney Special Report From ASCN/ A.S.P.E.N. Working Group on Standards for Aluminum Content of Parenteral Nutrition Solutions JPEN J Parenter Enteral Nutr, January 1, 1992; 16(1): 92 - 93. [PDF]