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Calcium Glycerophosphate as a Source of Calcium and Phosphorus in Total Parenteral Nutrition SolutionsDepartment of Nutritional Sciences, University of Guelph, Guelph, Ontario, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Department of Nutritional Sciences, University of Guelph, Guelph, Ontario, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Department of Nutritional Sciences, University of Guelph, Guelph, Ontario, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada Calcium glycerophosphate (CaGP) was tested as an alternative to calcium gluconate (CaGluc) and potassium mono- and dibasic phosphate (KPhos) as a source of Ca and P in total parenteral nutrition (TPN) solutions for piglets. Four-day-old piglets were infused for 7 days with a TPN solution that provided either 4.2 mmol Ca and 2.1 mmol P/kg/24 h as CaGluc and KPhos (the maxium quantities that can be provided using these sources), or 15.0 mmol Ca and 15.0 mmol P/ kg/24 h as CaGP. Ca and P retentions were more than six times greater (p < 0.01) in the piglets receiving CaGP (14.5 ± 0.2 vs 2.2 ± 0.3 mmol Ca/kg/24 h and 13.3 ± 0.4 vs 2.4 ± 0.1 mmol P/kg/24 h) (Mean± SEM). The ratio of Ca to fat-free dry weight, an indicator of bone mineralization, was significantly higher (p < 0.05) in the humerus (174.8 ± 2.2 vs 147.2 ± 6.7) and femur (158.3 ± 4.8 vs 130.1 ± 7.8) in the CaGP group. This study showed that CaGP is efficiently used as a source of Ca and P in TPN solutions for piglets. The results suggest that the use of CaGP as the source of Ca and P in TPN solutions may prevent the development of the undermineralized bone seen in low-birth weight infants nourished intravenously. (Journal of Parenteral and Enteral Nutrition 15:176-180, 1991)
Journal of Parenteral and Enteral Nutrition, Vol. 15, No. 2,
176-180 (1991) |
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