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Preincubation with Intravenous Lipid Emulsion Reduces Chemotactic Motility of Neutrophils in Cord Blood

Neonatal Intensive Care Unit, the Department of Neonatology, Zerifin and the University of Tel Aviv, Sackler School of Medicine, Tel Aviv, Israel

Shoshana Peller, PH.D.

Department of Hematology, Assaf Harofeh Medical Center, Zerifin and the University of Tel Aviv, Sackler School of Medicine, Tel Aviv, Israel

Eliana Arbel, M.D.

Neonatal Intensive Care Unit, the Department of Neonatology, Zerifin and the University of Tel Aviv, Sackler School of Medicine, Tel Aviv, Israel

Michael Goldberg, M.D.

Neonatal Intensive Care Unit, the Department of Neonatology, Zerifin and the University of Tel Aviv, Sackler School of Medicine, Tel Aviv, Israel

Neutrophils from cord blood of healthy term infants were isolated and incubated for 30 min with varying concentrations of intravenous lipid emulsion (ILE) solution (4, 8, 20 mg/ml). In vitro assay of chemotaxis was performed after incubation for 120 min with endotoxin-activated serum (EAS). Neutrophil random motility was unchanged after ILE incubation yet chemotactic factor (EAS)-stimulated motility was significantly reduced in a dose-related pattern. (Journal of Parenteral and Enteral Nutrition 14:472-473, 1990)

Journal of Parenteral and Enteral Nutrition, Vol. 14, No. 5, 472-473 (1990)
DOI: 10.1177/0148607190014005472


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